西洛他唑联合盐酸氨溴索治疗脑梗死老年患者肺炎临床疗效与预后  

Clinical efficacy of cilostazol combined with ambroxol hydrochloride in treatment of elderly cerebral infarction patients with pneumonia and prognosis

作　　者：陈松芳[1] 邵胜敏[1] 何志勇[1] 邹明[1] 吴志鹏 胡蓓蕾[1] 

机构地区：[1]温州医科大学附属第二医院神经内科,浙江温州325000 [2]温州市中西医结合医院神经科,浙江温州325000

出　　处：《中华医院感染学杂志》2015年第10期2270-2272,共3页Chinese Journal of Nosocomiology

基　　金：温州市科技局社会发展科学研究基金资助项目(Y20100291)

摘　　要：目的探讨西洛他唑联合盐酸氨溴索治疗脑梗死老年患者肺炎临床疗效及预后,以降低肺炎并发症。方法选取医院2011年7月-2014年7月脑梗死发生肺部感染患者90例,将患者随机分为对照组和治疗组,每组各45例,对照组在常规治疗基础上给予西洛他唑治疗,治疗组应用西洛他唑联合盐酸氨溴索治疗,治疗两周后进行临床疗效、咳嗽缓解时间、退热时间及住院时间评估,并应用巴氏指数(BI)评估患者生活质量;对比治疗前后白细胞(WBC)计数、C-反应蛋白(CRP)水平。结果治疗组总有效率为86.67%、对照组为75.56%,两组比较差异有统计学意义(P<0.05);治疗组咳嗽缓解时间、退热时间和住院时间分别为(7.56±1.43)d、(7.18±1.25)d和(26.45±2.08)d,均低于对照组,两组比较差异有统计学意义(P<0.05);治疗组患者BI为61.73±3.51,高于对照组,两组比较差异有统计学意义(P<0.05);治疗组患者WBC和CRP分别为(7.18±1.19)×109/L和(8.23±1.30)mg/L,均低于对照组患者治疗后,两组比较差异有统计学意义(P<0.05)。结论西洛他唑联合盐酸氨溴索治疗脑梗死老年患者肺炎具有较好的临床疗效,能够缩短治疗时间,改善患者预后。OBJECTIVE To observe the clinical efficacy of cilostazol combined with ambroxol hydrochloride in treat‐ment of the elderly cerebral infarction patients with pneumonia and analyze the prognosis so as to reduce the inci‐dence of complication of pneumonia .METHODS From Jul 2011 to Jul 2014 ,a total of 90 cerebral infarction pa‐tients with complicated pulmonary infections were enrolled in the study and randomly divided into the control group and the treatment group ,with 45 cases in each;the control group was treated with cilostazol on the basis of the conventional treatment ,while the treatment group was given cilostazol combined with ambroxol hydrochloride . After the treatments for two weeks ,the clinical efficacies ,cough remission time ,fever clearance time ,and length of hospital stay were evaluated ,the quality of life was assessed by using Barthel Index （BI） ,and the white blood cells counts and the level of C‐reactive protein （CRP） were determined and compared before and after the treat‐ments .RESULTS The total effective rate of the treatment group was 86 .67% ,the control group 75 .56% ,and there was significant difference between the two groups （P〈0 .05） .The cough remission time of the treatment group was （7 .56 ＆#177; 1 .43）days ,shorter than that of the control group;the fever clearance time of the treatment group was （7 .18 ＆#177; 1 .25）days ,shorter than that of the control group;the length of hospital stay of the treatment group was （26 .45 ± 2 .08）days ,shorter than that of the control group ,with statistical significance （P〈0 .05） . The BI of the treatment group was 61 .73 ±3 .51 ,significantly higher than that of the control group（P〈0 .05） . The WBC counts of the treatment group were （7 .18 ±1 .19）×10^9/L ,lower than those of the control group;the level of CRP of the treatment group was （8 .23 ± 1 .30）mg/L ,lower than that of the control group ,and there were significant differences between the two groups （P〈 0 .05） .CONCLUSION

关 键 词：西洛他唑 盐酸氨溴索 老年 脑梗死 肺炎 

分 类 号：R563.1[医药卫生—呼吸系统]