胎盘多肽注射液对四肢骨折术后感染预防效果的临床研究  

Clinical study of effect of placental peptide injection on prevention of postoperative infections in limb fractures patients

作　　者：胡涌亮 管四炎 王国庆 胡顺才 余斌 

机构地区：[1]衢州市柯城区人民医院骨科,浙江衢州324000

出　　处：《中华医院感染学杂志》2015年第10期2294-2296,共3页Chinese Journal of Nosocomiology

基　　金：浙江省卫生厅规划基金资助项目(ZW-2010B030)

摘　　要：目的探讨胎盘多肽注射液对四肢骨折术后感染的影响,提高临床诊治水平,降低骨折术后感染的发生。方法选取2010年2月-2014年3月66例四肢骨折术后感染患者为研究对象,随机进行分组,对照组32例,予常规抗菌药物治疗,观察组34例,加用胎盘多肽注射液治疗,对比两组患者治疗后感染控制时间、住院时间、渗液消失时间、皮肤愈合时间及感染C-反应蛋白(CRP)、白细胞计数(WBC)、白细胞介素-1(IL-1)、白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)等相关指标水平变化,同时对骨折愈合时间进行比较。结果观察组在感染控制时间、住院时间、渗液消失时间、皮肤愈合时间方面均低于对照组,两组比较差异有统计学意义(P<0.05);治疗前两组CRP、IL-1、IL-6、TNF-α、WBC 5项感染指标比较差异无统计学意义;治疗后两组上述感染相关指标均明显低于治疗前水平,治疗前后比较差异均有统计学意义(P<0.05),观察组治疗后的上述指标均低于对照组,两组比较差异有统计学意义(P<0.05);观察组四肢骨折的愈合时间均短于对照组,两组比较差异有统计学意义(P<0.05)。结论胎盘多肽注射液不仅能降低四肢骨折术后感染率,且能加快骨折愈合时间。OBJECTIVE To explore the effect of the placental peptide injection on postoperative infections in limb fracture patients so as to improve the clinical diagnosis and treatment and reduce the incidence of the postoperative infections .METHODS From Feb 2010 to Mar 2014 ,a total of 66 limb fracture patients with postoperative infec‐tions were recruited as the study objects and randomly divided into the control group with 32 cases and the obser‐vation group with 34 cases ;the control group was treated with conventional antibiotics ,while the observation group was given additional placental peptide injection .After the treatment ,the time of control of infections ,length of hospital stay ,time of disappearance of exudates ,and skin healing time were compared between the two groups ;the changes of the levels of related indicators for the infections ,including C‐reactive protein （CRP） ,white blood cells （WBC） counts ,interleulin‐1 （IL‐1） ,interleukin‐6 （IL‐6） ,and tumor necrosis factor‐α（TNF‐α） ,were ob‐served ,and the fracture healing time was compared .RESULTS The time of control of infections ,length of hospital stay ,time of disappearance of exudates ,and skin healing time were shorter in the observation group than in the control group ,and there was significant difference between the two groups （P〈0 .05） .There was no significant difference in the CRP ,IL‐1 ,IL‐6 ,TNF‐α,or WBC between the two groups before the treatment ;however ,the levels of the above infection‐related indicators of the two groups were significantly lower after the treatment than before the treatment（P〈0 .05）;after the treatment ,the levels of the above indicators of the observation group were lower than those of the control group ,and there was significant difference （P〈0 .05） .The healing time of the limb factures of the observation group was significantly shorter than that of the control group（P〈 0 .05） . CONCLUSION The placental peptide injection can not only reduce the

关 键 词：胎盘多肽注射液 四肢骨折 术后感染 影响性 

分 类 号：R619.3[医药卫生—外科学]