武汉市出生缺陷影响因素的病例对照研究  

Case-control study on influencing factors of birth defects

作　　者：龚瑞龙 张斌[2] 杨少萍[2] 赵瑾珠[2] 张丹[2] 彭安娜[2] 朱长才[1] 

机构地区：[1]武汉科技大学公共卫生学院,湖北武汉430065 [2]武汉市妇女儿童医疗保健中心,湖北武汉430016

出　　处：《中国儿童保健杂志》2015年第5期503-505,共3页Chinese Journal of Child Health Care

基　　金：湖北省自然科学基金(jry1633)

摘　　要：目的探讨武汉市中心城区出生缺陷的影响因素,为出生缺陷干预提供科学依据。方法采用1∶4配对病例对照研究,对386例出生缺陷儿的产妇、1 544例正常儿的产妇进行回顾性调查。使用SAS9.2统计软件进行统计分析,采用描述性统计分析、单因素Logistic回归分析和多因素1∶4匹配条件Logistic回归分析方法。结果有统计学意义的因素有:产妇孕期接触致畸因素(OR=1.602)、被动吸烟(OR=1.002)、孕期健康状况好(OR=0.943)、孕期坚持运动(OR=0.955)、剖宫产(OR=0.863)和曾分娩活产次数(OR=0.712)。结论产妇孕期接触致畸因素和被动吸烟是出生缺陷的危险因素,孕期健康状况好、孕期坚持运动、剖宫产和曾分娩活产次数是出生缺陷的保护因素。Objective To investigate the risk factors of birth defects in center of Wuhan city,and to provide scientific evidence for the interventions. Methods A 1 ： 4 matched case-control study was conducted,386 mothers of birth defects children and 1 544 controls were investigated retrospectively. Data were analyzed for descriptive study, univariate Logistic re- gression and 1 ： 4 matched conditional Logistic regression with SAS9.2 statistical software. Results The following fac- tors were found to be significantly related to birth defects：maternal exposure to teratogenic factors during pregnancy （OR= 1. 602） ,passive smoking （OR= 1. 002） ,good state of health during pregnancy （OR=0. 943） ,adhere to exercise during preg- nancy （OR=0. 952） ,cesarean section（OR=0. 853） and once the number of live births childbirth （OR=0. 712）. Conclu- sion Maternal exposure to teratogenic factors during pregnancy and passive smoking are risk factor for birth defects,good state of health during pregnancy, adhere to exercise during pregnancy, cesarean section and the number of live births are pro- tective factors for birth defects.

关 键 词：出生缺陷 病例对照 LOGISTIC回归分析 

分 类 号：R174[医药卫生—妇幼卫生保健]