复方醋酸棉酚片溶出度测定  

Determination of Dissolution Rate of Compound Gossypol Acetate Tablets

作　　者：刘增平 黄洁 

机构地区：[1]陕西省延安市食品药品检验所,陕西延安716000 [2]陕西省西安市食品药品检验所,陕西西安710054

出　　处：《中国药业》2015年第10期62-63,共2页China Pharmaceuticals

摘　　要：目的建立测定复方醋酸棉酚片溶出度的方法。方法采用0.3%聚山梨酯的磷酸钠缓冲液（p H=8.0）1 000 m L为溶出介质,溶出方法为桨法,转速为75 r/min。结果复方醋酸棉酚片溶出度的线性回归方程为Y=0.021 6 X-0.005 4（r=1,n=5）,线性范围为5.10-25.50μg/m L;平均回收率为99.56%,RSD=0.51%（n=9）。结论该方法简便快捷、回收率高、结果准确,可作为复方醋酸棉酚片溶出度的测定方法。Objective To establish a determination method of the dissolution rate of Compound Gossypol Acetate Tablets. Methods 0. 3% polysorbate sodium phosphate buffer（pH=8. 0）1 000 mL was adopted as the dissolution medium. The dissolution method was the paddle method. The rotation speed was 75 r/min. Results The linear equation of dissolution rate of Compound Gossypol Acetate Tablets was Y=0. 021 6 X-0. 005 4（ r=1,n=5）,the linear range was 5. 10-25. 50 μg/mL. The average recovery rate was 99. 56%, RSD=0. 51%（ n=9）. Conclusion This method is simple,convenient,and accurate with high recovery rate,and serves as the determi-nation method of dissolution rate of Compound Gossypol Acetate Tablets.

关 键 词：复方醋酸棉酚片 溶出度 分光光度法 

分 类 号：R927.11[医药卫生—药学] R984