移动差值控制图评估临床实验室肌钙蛋白不确定度  

Evaluation on determination uncertainty of cTnI in clinical laboratory with mobile difference control chart

作　　者：李丽[1] 李小佩[1] 王建新[1] 施英娟[1] 顾文超[1] 王惠民[1] 

机构地区：[1]南通大学附属医院检验科,江苏南通226001

出　　处：《检验医学与临床》2015年第9期1218-1219,1222,共3页Laboratory Medicine and Clinic

基　　金：南通大学自然科学基金(13Z018)

摘　　要：目的运用控制图评估肌钙蛋白I(cTnI)测量不确定度。方法采用日本东曹AIA-1800全自动荧光磁微粒酶免分析仪测定cTnI控制品,1次/天,共30d;用Anderson-Darling法检验数据的正态分布性和独立性;建立单值-移动差值及指数加权移动平均值控制图及评估不确定度。结果 Anderson-Darling检验cTnI质控数据为正态分布性且具有独立性,结果测量不确定为(0.218±0.016)μg/L,(k=2)。结论移动极差控制图法可用来评估cTnI结果不确定度,本研究为临床实验室评价不确定度提供了新的思路。Objective To use the control chart technique for evaluating the measurement uncertainty of cTnI . Methods The control of cTnI was detected by TOSOH AIA‐1800 automatic enzyme immunoassay system once a day for 30 d .The Anderson‐Darling method was adopted to test the normal distribution and independence of the cTnI da‐ta;the control chart of single value ,mobile difference and exponentially weighted moving average was established and the uncertainty was evaluated .Results The Anderson‐Darling test showed that the cTnI quality control data were the normal distribution with independence .The measurement uncertainty of cTnI was （0 .218 ± 0 .016）μg/L ,（k=2） .Conclusion The mobile difference control chart could be used to evaluate the uncertainty of cTnI results .This re‐search provides a new idea for clinical laboratory evaluating the measurement uncertainty .

关 键 词：移动差值控制图 不确定度 肌钙蛋白I 

分 类 号：R197.324[医药卫生—卫生事业管理]