糖化血红蛋白对前驱糖尿病诊断和监测的临床意义  

Clinical significance of glycosylated hemoglobin on diagnosis and monitoring of prediabetes

作　　者：李晓艳[1] 邱晓沛 张洪 刘星 罗阳 

机构地区：[1]成都军区机关医院内分泌科,610011 [2]第三军医大学第一附属医院输血科,重庆400038

出　　处：《检验医学与临床》2015年第9期1233-1234,1237,共3页Laboratory Medicine and Clinic

摘　　要：目的探讨糖化血红蛋白检测在前驱糖尿病诊断和监测的临床意义。方法对434例成都军区机关医院内分泌科门诊就诊者进行空腹血糖、餐后2h血糖和糖化血红蛋白测定,并对其结果进行统计学分析。结果前驱糖尿病组118例,空腹血糖(6.48±0.52)mmol/L,餐后2h血糖(9.55±1.38)mmol/L,糖化血红蛋白(5.83±0.22)%;糖尿病组145例,空腹血糖(13.81±2.12)mmol/L,餐后2h血糖(19.33±3.79)mmol/L,糖化血红蛋白(10.12±0.45)%;均高于健康对照组(171例)的空腹血糖(5.31±0.78)mmol/L,餐后2h血糖(6.05±1.12)mmol/L,糖化血红蛋白(4.72±0.51)%,差异均有统计学意义(P<0.05)。糖化血红蛋白与空腹血糖和餐后2h血糖均呈正相关(P<0.05)。糖化血红蛋白诊断糖尿病的敏感度和特异性为100.0%,诊断前驱糖尿病的敏感度为97.5%,特异性为100.0%。结论糖化血红蛋白能够有效区分前驱糖尿病和糖尿病,对于糖尿病的治疗监控具有重要意义。Objective To discuss the clinical significance of glycated hemoglobin in diagnosis and monitoring of pre‐diabetes mellitus（DM ） .Methods The fasting blood glucose ,2 h postprandial blood glucose and glycosylated he‐moglobin in 434 outpatients in the endocrinological clinic of the Institution Hospital of Chengdu Military Region were detected and the results were statistical analyzed .Results In the pre‐DM group（118 cases） ,the fasting blood glucose was（6 .48 ± 0 .52）mmol/L ,2 h postprandial blood glucose was（9 .55 ± 1 .38）mmol/L and glycosylated hemoglobin was（5 .83 ± 0 .22）% ;in the diabetes group（145 cases） ,the fasting blood glucose was（13 .81 ± 2 .12）mmol/L ,2 h postprandial blood glucose was（19 .33 ± 3 .79）mmol/L and glycosylated hemoglobin was（10 .12 ± 0 .45）% ;in the control group（171 cases） ,the fasting blood glucose was（5 .31 ± 0 .78）mmol/L ,2 h postprandial blood glucose was （6 .05 ± 1 .12） mmol/L and glycosylated hemoglobin was（4 .72 ± 0 .51）% ,the differences were statistically signifi‐cance（P〈0 .05） .Glycosylated hemoglobin level was positively correlated with fast glucose and 2 h postprandial blood glucose （P〈0 .05） .The sensitivity and specificity of glycated hemoglobin for diagnosing DM were 100 .0% and its sensitivity and specificity for diagnosing pre‐DM were 97 .5% and 100% respectively .Conclusion Glycated hemoglo‐bin can effectively differentiate diabetes from pre‐DM ,which has an important significance in the treatment and moni‐toring of DM .

关 键 词：前驱糖尿病 空腹血糖 糖化血红蛋白 诊断 

分 类 号：R587.1[医药卫生—内分泌]