COX-2和GLUT-1在尖锐湿疣组织中的表达及意义  

Expression and significance of COX-2 and GLUT-1 in condyloma acuminatum

作　　者：蔡丙杰[1] 尹光文[1] 

机构地区：[1]郑州大学第一附属医院皮肤科,郑州450052

出　　处：《医药论坛杂志》2015年第4期3-4,7,共3页Journal of Medical Forum

基　　金：河南省重点科技攻关项目(132102310517);河南省教育厅科学技术研究重点项目(13A320426)

摘　　要：目的探讨尖锐湿疣(CA)组织中COX-2和GLUT-1的表达及意义。方法采用免疫组化SP法检测38例CA组织中COX-2和GLUT-1的表达。结果 CA组织中COX-2和GLUT-1阳性表达率分别为73.68%(28/38)和89.47%(34/38),正常对照组COX-2和GLUT-1阳性表达率分别为0.00%(0/20)和30.00%(6/20);CA组织中COX-2和GLUT-1阳性表达强度多在++^+++,正常对照组多在-^+;CA组和对照组中COX-2和GLUT-1阳性表达率及表达强度均有统计学意义(P<0.05)。CA组织中COX-2与GLUT-1表达强度间存在正相关性(r=0.66,P<0.05)。结论 CA组织中存在COX-2和GLUT-1过表达,COX-2和GLUT-1在促进CA细胞增殖和能量代谢中可能发挥重要作用。Objective To explore the expression and significance of COX- 2 and GLUT- 1 in lesions of Condyloma Acuminatum（ CA）. Methods We used SP immunohistochemistry method to measure the expression of COX- 2 and GLUT- 1 in 38 cases of CA and 20 normal skin controls. Results The positive rates of COX- 2 and GLUT- 1were73. 64%（ 28 /38） and 89. 47%（ 34 /38） in CA tissues,meanwhile 0. 00%（ 0 /20） and 30. 00%（ 6 /20） in the controls. The expression intensity of COX- 2 and GLUT- 1 in CA was significant higher（ ＋ ＋ - ＋ ＋ ＋） than that in normal controls（- - ＋）（ P 〈0. 05）. Both the positive expression rate and expression intensity of COX- 2 and GLUT- 1 compared with normal group differences were statistically significant. The positive correlation was observed between the expression of COX- 2 and GLUT- 1（ r = 0. 66,P〈0. 05）. Conclusion The higher expression of COX- 2 and GLUT- 1 may play an important role in promoting the proliferation and providing energy metabolism of CA cells.

关 键 词：尖锐湿疣 COX-2 GLUT-1 

分 类 号：R752.5[医药卫生—皮肤病学与性病学]