枸橼酸咖啡因与多索茶碱治疗早产儿原发性呼吸暂停疗效比较  

Comparson of curative effect of caffeine citrate and doxofyline in treatment of prematurity primary apnea

作　　者：吴星[1] 孙健伟[1] 周长江[1] 张家洁[1] 

机构地区：[1]河南省人民医院儿科,郑州450000

出　　处：《医药论坛杂志》2015年第4期34-35,共2页Journal of Medical Forum

摘　　要：目的探讨枸橼酸咖啡因与多索茶碱治疗早产儿呼吸暂停(AOP)的疗效。方法选择2014年1月至2015年1月在河南省人民医院新生儿科接受住院治疗的出生胎龄<34周、出生体质量<1 500 g的极低出生体质量和超低出生体质量儿42例。随机分为枸橼酸咖啡因组(21例,枸橼酸咖啡因首剂负荷量20 mg/kg,24 h后给予维持量5 mg/kg,1次/d,静脉泵入)多索茶碱组(21例,首剂负荷量5 mg/kg,12 h后给予维持量2 mg/kg,每12 h 1次,静脉泵入),对比二组的治疗效果及不良反应。结果枸橼酸咖啡因组效果明显高于多索茶碱组,差异有统计学意义,且不良反应较少。结论咖啡因治疗早产儿呼吸暂停疗效优于氨茶碱,安全有效。Objective To examine the curative effect of caffeine citrate and doxofyline in the treatment of primary apnea of prematurity（AOP） Methods Choosing 42 cases of hospitalized premature （ birth gestational age 〈 34 weeks） and underweight（birth weight 〈 1500g） babies with very low birth weight or ultra low birth weight who received treatment in neonatal wards in Henan Provencal Peoples Hospital from January 2014 to January 2015. Two groups were divided randomly, group of caffeine citrate（21 cases, the first loading dose of the caffeine citrate is 20 mg/kg, and after 24 hours, a maintenance dose is given at 5 mg/kg, 1 time a day, with intravenous pumping） and group of doxofyline（21cases, the first loading dose of the doxofyline is 20 mg/kg, and after 12 hours, a maintenance dose is given at 2 mg/kg, 1 time per 12 hours, with intravenous pumping）. Compare the curative effect and the adverse drug effect of the two groups. Results The curative effect of the caffeine citrate is evidently better than that of the caffeine doxofyline group. The differences are statistically significant, in addition, the adverse effect is comparatively less. Conclusion The curative effect of caffeine citrate is better than that of doxofyline in the treatment of primary apnea of prematurity, with safety and effectiveness.

关 键 词：呼吸暂停 枸橼酸咖啡因 多索茶碱 

分 类 号：R722.6[医药卫生—儿科]