血清肝细胞生长因子检测在2型糖尿病肾病中的诊断价值  

Combined detection of serum levels of hepatocyte growth factor, homocysteine and diagnostic value of index in type 2 diabetic nephropathy

作　　者：孙春秀[1] 杜秋香[2] 徐宁[1] 左江华[1] 张彦芳[1] 田连芳[1] 王新荣[1] 马景枝[3] 

机构地区：[1]邢台市人民医院检验二科,河北邢台054000 [2]邯郸市第三医院检验科,河北邯郸056001 [3]河北医科大学第四医院检验科,河北石家庄050011

出　　处：《中国医学装备》2015年第4期92-94,共3页China Medical Equipment

摘　　要：目的：探讨检测血清肝细胞生长因子（HGF）、同型半胱氨酸（Hcy）和尿微量白蛋白（Um Alb）与尿肌酐（UCr）比值在2型糖尿病肾病中的诊断价值。方法：依据24 h Um Alb的定量检测结果,将91例2型糖尿病患者分为A组（30例）、B组（31例）和C组（30例）;并选择30名健康者为对照组。A组为糖尿病无肾病组（Um A1b〈30 mg/24 h）;B组为早期糖尿病肾病组（EDN）（Um Alb30-300 mg/24 h）;C组为糖尿病明显肾病组（ADN）（Um Alb〉300 mg/24 h）。对3组患者进行HGF、Hcy、Um Alb以及UCr含量检测,并与对照组进行比较。结果：1B组和C组血清检测结果均显著高于健康对照组和A组,差异有统计学意义（t=1.86,P〈0.05）;2C组水平高于B组,差异有统计学意义（t=2.01,P〈0.05）。结论：检测血清HGF、Hcy、Um Alb以及UCr对2型糖尿病肾病早期诊断及病情监测具有重要价值。Objective： To investigate the effect of combined detection of serum hepatocyte growth factor （hepatocyte growth facto R, HGF）, homocysteine （Hcy） and urinary albumin （UmAlb） and urinary creatinine （UCr） ratio in the diagnosis of type 2 diabetic nephropathy. Methods： Based on the quantitative determination of albumin in 24 h urine results in 91 patients with type 2 diabetes mellitus patients were divided into 3 groups：group A was non DN group （UmA1b＆〈30 mg/24 h） in 30 cases, B group for the early diabetic nephropathy group （EDN） （UmAlb 30 mg-300mg/24h） in 30 cases, C group. Disease overt nephropathy group （AND） （UmAlb＆〉300 mg/24 h） in 30 cases. For detection of serum HGF, Hcy and UmAlb, Ucr content of the 3 groups of patients, and compared with 30 healthy control groups. Results：（1） in B group and C group were significantly higher than that of healthy control group and A group, （t=1.86, P〈0.05）, C group （2） was higher than that of B group, the difference was statistically significant（t=2.01, P〈0.05）. Conclusion：It has important value of combined detection of serum HGF, Hcy and UmAlb/Ucr to early diagnosis of type 2 diabetic nephropathy fault and condition monitoring.

关 键 词：2型糖尿病肾病 肝细胞生长因子 同型半胱氨酸 尿微量白蛋白 尿肌酐 

分 类 号：R587.1[医药卫生—内分泌]