肺心病患者治疗前后肺循环血流变化及有关指标的相关性分析  

Correlation Analysis between before and after Treatment in Patients with Chronic Pulmonary Heart Disease Andpulmonary Circulation of Blood Changes and Related Indexes

作　　者：方小桂 童芳芳[1] 何克刚 时雪飞 

机构地区：[1]潜江市中心医院,湖北潜江433100

出　　处：《亚太传统医药》2015年第9期69-71,共3页Asia-Pacific Traditional Medicine

摘　　要：目的:探讨肺心病患者治疗前后肺循环血流变化及血浆D-二聚体水平和肺动脉收缩压及二氧化碳分压的变化情况。方法:回顾性分析经中西医结合治疗后的50例肺心病患者的临床资料,作为观察组,取30例健康者为对照组,测定其血浆D-二聚体(D-dimer)、肺动脉收缩压(SPAP)及二氧化碳分压(PaCO2),比较对照组与观察组及观察组治疗前后数据间关系。结果:观察组PaCO2较对照组显著升高,观察组患者的血浆D-dimer水平明显高于对照组,两组比较差异均有统计学意义(P<0.05);PaCO2与血浆D-dimer水平呈显著正相关(r=0.214,P<0.05);治疗后合并肺动脉高压患者28例,非合并肺动脉高压患者26例,合并肺动脉高压患者的血浆D-dimer水平显著高于后者,差异有统计学意义(P<0.05)。结论:肺心病患者由于缺氧、酸中毒及高碳酸血症,血管内皮负担加重,阻滞微循环,进入血栓前期;肺心病患者血液凝血状态异常,肺部微小血栓形成是导致肺动脉高压的原因之一;高碳酸血症是导致血液凝血状态异常的原因之一。Objective：To investigate the changes before and after treatment in patients with pulmonary heart disease pulmonary blood flow and plasma D- two level of D-dimer and pulmonary artery systolic pressure andpartial pressure of carbon dioxide. Meth- ods： Retrospective analysis of the combination of traditional Chinese and Western medicine treatment of 50 cases of pulmonary heart disease patients, as the observation group, 30 cases of healthy persons as control group, the content of the plasma D- dimer （D-di- mer two）, pulmonary artery systolic pressure （SPAP） and carbon dioxide partial pressure （PaCOz）, compared with control group after observationgroup and the observation group treatment the relationship between data. Results： In the observation group, PaCO2 was significantly increased compared with the control group, the observation group the plasma D-dlmer level was significantly higher than the control group, two groups of comparisons difference was statistically significant （P〈0.05） ; PaCO2 was positively correla- ted with plasma D-dimer levels （r=0. 214, P〈0.05）; after the treatment of 28 cases with pulmonary hypertension, 26 cases pa- tients with pulmonary hypertension, the plasma D-dimer level in patients with pulmonary hypertension were significantly higher than that of the latter, the difference was statistically significant （P〈0.05）. Conclusion： The patients with pulmonary heart disease due to hypoxia andhypercapnia, acidosis, vascular endothelial burden, block the microcirculation, enter the pre thrombosis;Pulmo- nary heart disease patients blood coagulation abnormalities, pulmonary micro thrombosis is one of the leading causes of pulmonary hypertension, hypercapnia is one of the leading causes of abnormal blood coagulation state.

关 键 词：肺心病 D-二聚体 肺动脉收缩 二氧化碳 相关性 

分 类 号：R541.5[医药卫生—心血管疾病]