痤疮涂膜剂联合红、蓝光照射治疗中重度痤疮的临床研究  

Combination of red and blue light therapy with acne film coating in treatment of moderate and severe acne

作　　者：孟繁俊[1] 张玉霞[2] 韩传恩[1] 

机构地区：[1]河南省商丘市第一人民医院皮肤科,476100 [2] 河南省商丘医学高等专科学校科研处

出　　处：《中华全科医师杂志》2015年第5期370-373,共4页Chinese Journal of General Practitioners

基　　金：河南省科技攻关计划项目（142102310204）

摘　　要：目的 了解痤疮涂膜剂和红、蓝光照射联合治疗中、重度痤疮的疗效及安全性.方法 对我院门诊2012年3月至2014年7月诊治的547例中、重度痤疮患者,按就诊顺序循环将患者分为3个治疗组,观察组183例及对照1组182例、对照2组182例,3组中中、重度患者各为130和53例、130和52例,129和53例.观察组采用痤疮涂膜剂和红、蓝光照射联合治疗,红光和蓝光每周各照射1次、间隔3d,痤疮涂膜剂每日应用1次;对照1组仅用痤疮涂膜剂治疗,每日1次;对照2组仅行红、蓝光交替照射治疗,每周各1次,3组均治疗6周.记录治疗前和治疗2、4、6周后的皮损数目,治疗后第10周评价疗效.结果 3组患者治疗后皮损数均较治疗前有不同程度的减少,治疗6周时减少最明显,3组中观察组皮损数减少最为明显.中度痤疮的总有效率,观察组为84.6％ （110/130）,对照1组为58.5％ （76/130）,对照2组为51.9％ （67/129）,观察组与对照1、2组比较,差异均有统计学意义（χ2值分别为21.836和31.955,均P＜0.01）;重度痤疮的总有效率,观察组为84.9％ （45/53）,对照1组为57.7％（30/52）,对照2组为56.6％ （30/53）,观察组与对照1、2组比较,差异均有统计学意义（χ2值分别为9.525和10.258,均P＜0.01）.观察组治疗中共有20例（10.9％）出现不良反应,表现为红斑、瘙痒、灼热和刺痛感,对照1、2组出现不良反应者分别为14和22例（7.7％和12.1％）,均能耐受.结论 痤疮涂膜剂和红、蓝光交替照射联合治疗中、重度痤疮,比采用单一治疗方案效果好,且安全.Objective To evaluate the efficacy of combined red and blue light therapy with acne film coating in treatment of moderate and severe acne.Methods Totally 547 patients with moderate or severe acne were enrolled in the study from March 2012 to July 2014.Using open control,according to the cycle of time sequence will patients were divided into three groups：183 patients （study group） were received alternatively red and blue light therapy twice a week,and acre film coating was applied once a day;182 patients in control group 1 received film coating alone and another 182 patients （control group 2） received light therapy alone.The treatment lasted for 6 weeks in all three groups.The numbers of skin lesions were recorded before and 2,4,6 w after treatment,and the curative effect was evaluated 10 w after treatment.Results The number of skin lesion were significantly reduced 6w after treatment in all three groups,that for study group was most markedly.For patients with moderate acne,the total effective rates in study group and in control groups 1 and 2 were 84.6% （110/130）,58.5% （76/130） and 51.9% （67/129）,respectively （x2 =21.836,and 31.955,P 〈0.01）.For patients with severe acne the total effective rates in study group and in control groups 1 and 2 were 84.9% （45/53）,57.7% （30/52） and 56.6% （30/53）,respectively （χ2 =9.525 and 10.258,P 〈0.01）.There are 20 cases in observation group therapy for different degree of erythema,itching,burning,tingling,incidence of side effects was 10.9% （20/183）,control group 1 and 2 were 7.1% （14/182）,12.1% （22/182）,are tolerated.Conclusion The combination of red/blue light therapy with acne film coating is more effective than the application of single method alone for patients with moderate or severe acne.

关 键 词：痤疮 寻常 光疗法 丙酸杆菌 痤疮 投药 局部 

分 类 号：R758.733[医药卫生—皮肤病学与性病学]