经颅脑肿瘤HIFU治疗技术的研究现状  

Status in the HIFU Treatment Technology about Transcranial Brain Tumor

作　　者：韩珍珍[1] 菅喜岐[1] 

机构地区：[1]天津医科大学生物医学工程与技术学院,天津300070

出　　处：《生命科学仪器》2015年第2期7-13,38,共8页Life Science Instruments

基　　金：国家自然科学基金资助项目:经颅脑肿瘤HIFU治疗温度场的研究(81272495)

摘　　要：高强度聚焦超声作为一种非侵入性、无毒副作用的肿瘤治疗手段,目前已应用于乳腺癌、子宫肌瘤等的临床治疗。但对无创经颅高强度聚焦超声脑肿瘤治疗而言,由于颅骨的非均质结构及其声学特性导致经颅超声的相位和幅值失真,引发颅内散焦、焦点偏移和颅骨周围正常组织损伤等临床问题的发生。近年来随着经颅超声相控换能器及其控制技术的发展,高强度聚焦超声经颅脑肿瘤治疗成为可能。本文就近年来经颅脑肿瘤HIFU治疗的相关技术进行综述。As a non-invasive technique with non-toxic side effects, high intensity focused ultrasound （HIFU） has been used in clinic treatment which includes breast cancer, uterine fibroids. However, as for non-invasive transcranial treatment of brain tumors, the phase and amplitude distortion of transcranial ultrasound which caused by the heterogeneous nature and acoustic characteristics of the skull lead to defocus and distort and shift the intracranial acoustic focus as well as heating at the patient＇s skull and surrounding normal tissue. In recent years, phased array transducer and its control technology have made great process, which makes it possible high intensity focused ultrasound transcranial brain tumors treatment. This review focuses on recently HIFU treatment technology about transcranial brain tumor.

关 键 词：相控换能器 经颅治疗 时间反转法 阵元参数 

分 类 号：S858.292[农业科学—临床兽医学]