小牛血去蛋白提取物对糖尿病肾病患者24h尿蛋白定量的影响  

作　　者：唐景华[1] 李骏[1] 

机构地区：[1]广东省佛山市高明区人民医院内分泌科,528500

出　　处：《浙江临床医学》2015年第5期681-682,共2页Zhejiang Clinical Medical Journal

基　　金：广东省佛山市卫生局医学科研课题（2014202）

摘　　要：目的观察小牛血去蛋白提取物对糖尿病肾病患者24h尿蛋白定量的影响。方法采用单盲法，将118例24h尿蛋白定量升高的糖尿病肾病患者随机分为观察组（38例）和对照组（80例），两组患者均常规降糖治疗，疗程均为2周，观察组加用注射用小牛血去蛋白提取物800mg静脉滴注，1次／d，对照组加安慰剂O．9％氯化钠注射液250ml，静脉滴注。观察两组患者治疗前后24h尿蛋白定量变化及不良反应。结果两组治疗前24h尿蛋白定量比较差异无统计学意义（z=1．100，P=0．270）；观察组治疗后24h尿蛋白定量明显降低，与对照组比较，差异有统计学意义（z=-5．373，P=0．000）；对照组治疗前、后24h尿蛋白定量比较，差异无统计学意义（z=0．375，P=0．707）；两组患者在治疗期间均未出现不良反应。结论小牛血去蛋白提取物具有降低糖尿病肾病患者24h尿蛋白定量的作用，安全有效，值得临床推广。Objective To observe effect of 24-hour urinary protein excretion with deproteinized calf blood protein extractives treatment in diabetic nephropathy patients. Methods Using single-blind method, 118 diabetic nephropathy patients with high 24-hours urinary protein excretion randomly assigned into control group （ 80cases ） and treatment group （ 38 cases ） ; Two groups of patients had routine hypoglycemic treatment for two weeks;in treatment group, they were combined with the deproteinized calf blood extractives （ 800mg a day, intravenous ） , the control group were only treated with placebo of 0.9% saline 250ml, intravenous infusion;the patients were observed 24-hour of urinary protein excretion and adverse reactions before and after treatment. Results Before treatment, 24-hour urinary protein was no significant difference in the two groups （ Z=-1.100, P=0.270 ） ;After the treatment, 24-hour urinary protein excretion in the treatment group was significantly lower （ Z=-5.373, P=0.000 ） , which was not changed significantly in the control group （ Z=-0.375, P=0.707 ） ;two groups of patients had no adverse reactions during treatment.Conclusion Deproteinized calf blood extractives has the role of reducing 24-hour urinary protein in diabetic nephropathy patients, and it is safe and effective, worthy of clinical application.

关 键 词：小牛血去蛋白提取物 糖尿病肾病 24H尿蛋白定量 

分 类 号：R975[医药卫生—药品]