前列腺增生症患者更换α1-受体阻滞剂的原因分析  

Analysis of the reasons for replacement of α1-receptor blocker in patients with benign prostate hyperplasia

作　　者：彭海[1] 冉青[2] 

机构地区：[1]四川省第四人民医院泌尿外科,成都610016 [2]四川省人民医院泌尿外科

出　　处：《西南国防医药》2015年第5期479-481,共3页Medical Journal of National Defending Forces in Southwest China

摘　　要：目的分析前列腺增生症(BPH)患者,治疗期间更换α1-受体阻滞剂的原因。方法回顾性分析我院诊治的BPH患者共890例,分别予4种不同的α1-受体阻滞剂(多沙唑嗪、阿呋唑嗪、特拉唑嗪、坦索洛辛)治疗,分析药物更换率、更换药物的原因和治疗效果。结果 132例更换过药物,药物更换率为14.8%(132/890)。患者更换药物的原因中,疗效不佳占38.6%,副作用大占36.4%,体位性低血压占16.7%,药价偏高占3.8%,服药不便占4.6%。在坦索洛辛药物组中,药物更换率(9.5%)和因体位性低血压而更换药物的发生率(4.2%)都明显低于其他组(P<0.05)。结论 BPH患者治疗期间更换α1-受体阻滞剂的主要原因为疗效不佳和副作用大,服用坦索洛辛组的患者,药物更换率和因体位性低血压而更换药物的发生率较其他3种药物的患者低,值得首诊患者推荐使用,以降低药物更换率。Objective To analyze the reasons for replacement of α1-receptor blocker in patients with benign prostate hyperplasia （BPH） during treatment. Methods A retrospective analysis was made on the data about 890 patients with BPH to receive treatment in our hospital; four different α1-receptor blockers （doxazosin, alfuzosin, terazosin, and tamsulosin） were administered, and the medicine replacement rate, reason for the medicine replacement, and the therapeutic effects were compared and analyzed. Results Total 132 ones had to replace the medicine during the treatment, with a medicine replacement rate of 14.8% （132/890）. Among the reasons for medicine replacement, poor effect accounted for 38.6%, severe side effect accounted for 36.4%, orthostatic hypotension accounted for 16.7%, medicine price accounted for 3.8%, and inconvenience in administration accounted for 4.6%. In tamsulosin group, the medicine replacement rate （9.5%） and the incidence of medicine replacement due to orthostatic hypotension （42%） were significantly lower than those in the other drug groups （P 〈 0.05）. Conclusion The main reasons for replacement of α1-receptor blocker for patients with BPH during treatment include poor effect and severe side effect. The patients taking tamsulosin have lower medicine replacement rate and the incidence of medicine replacement due to orthostatic hypotension than those taking other three kinds of medicine, so tamsulosin is worthy of promotion to be used in the first diagnosis of the patients in order to reduce medicine replacement rate.

关 键 词：前列腺增生症 Α1-受体阻滞剂 换药 原因 

分 类 号：R711.32[医药卫生—妇产科学]