老年肺炎患者联合检测PCT和CRP的临床意义  

Clinical significance of combined detection of PCT and CRP in senile patients with pneumonia

作　　者：李鸿雁[1] 余开选[1] 袁晶[1] 李龙心[1] 杨雪[1] 

机构地区：[1]成都军区总医院干部病房,成都610083

出　　处：《西南国防医药》2015年第5期498-500,共3页Medical Journal of National Defending Forces in Southwest China

摘　　要：目的探讨联合检测降钙素原(PCT)和C-反应蛋白(CRP)对老年细菌性肺炎的临床意义。方法收集76例老年细菌性肺炎患者为肺炎组,以同期76例非细菌感染的老年患者为对照组,于入院时、入院8 d后,分别抽取静脉血检测PCT和CRP。结果入院时肺炎组PCT及CRP水平显著高于对照组(P<0.01);治疗8 d后,肺炎组CRP及PCT水平显著回落,与对照组无显著性差异(P>0.05)。CRP和PCT诊断肺炎的敏感性均较高,差异无统计学意义(P>0.05);联合检测CRP和PCT诊断肺炎的特异性显著高于单独检测PCT或CRP(P<0.05),而敏感性无明显差异。结论对老年细菌性肺炎,血清CRP和PCT均为敏感指标,但联合检测可提高特异性,对准确诊断具有临床意义。Objective To explore the clinical significance of combined detection of procalcitonin （PCT） and C-reactive protein （CRP） in senile patients with pneumonia. Methods 76 senile patients with bacterial pneumonia were collected to constitute a pneumonia group, and 76 senile ones with non-bacterial infection constituted a control group. In the admission to hospital and the eighth day in the hospital, detection of venous blood PCT and CRP were made respectively. Results In the admission to hospital, the PCT and CRP levels of the patients in the pneumonia group were significantly higher than those in the control group （P 〈 0.01）; after treatment for eight days,the CRP and PCT levels in the pneumonia group fell significantly and had no significant difference from those in the control group （P 〉 0.05）. The sensitivity of both CRP and PCT in the diagnosis of pneumonia was high, and there was no significant difference （P 〉 0.05）; the specificity of combined detection of CRP and PCT in the diagnosis of pneumonia was significantly higher than that of single detection of PCT or CRP （P 〈 0.05）, while there was no significant differences in sensitivity. Conclusion Both serum CRP and PCT are sensitive indexes to the diagnosis of bacterial pneumonia in senile patients, but joint detection of them can improve the specificity.

关 键 词：降钙素原 C-反应蛋白 肺炎 细菌感染:老年 

分 类 号：R563.1[医药卫生—呼吸系统]