紫杉醇聚乳酸纳米粒的制备及特性考察  

A Study on Preparation and Characterization of Paclitaxel Loaded Poly( D,L-lactic acid) Nanoparticles

作　　者：李平生[1,2] 

机构地区：[1]武汉大学基础医学院,湖北武汉430071 [2]湖北科技学院附属第二医院

出　　处：《湖北科技学院学报（医学版）》2015年第2期104-105,共2页Journal of Hubei University of Science and Technology(Medical Sciences)

摘　　要：目的制备紫杉醇聚乳酸纳米粒并考察其特性。方法采用超声乳化法制备紫杉醇聚乳酸纳米粒,动态光散射粒径仪测定粒径大小,透射电镜表征表面形态,HPLC测定包封率及载药量。结果紫杉醇聚乳酸纳米粒的平均粒径为(230.00±1.08)nm,包封率为(93.57±0.50)%,载药量为(3.01±0.03)μg/mg。结论该方法制备紫杉醇纳米粒工艺简单,方法可行。Objective To prepare the paclitaxel loaded poly（ D,L-lactic acid） nanoparticles. Methods Paclitaxel loaded poly（ D, L-lactic acid） nanoparticles were prepared by ultrasound emulsification, particle size was measured by dynamic light scatter, surface morphology was characterized by TEM, entrapment efficiency and drug loading was determined by HPLC. Results The average diameter of nanopaeticles was （230 ±1.08 ） nm, the entrapment efficiency and drug loading were （ 93.57± 0.50 ） %, （ 3.01 ± 0.03 ） μg/mg. Conclusion The preparation procedure of paclitaxel nanoparticles is simple and feasible

关 键 词：紫杉醇 聚乳酸 纳米粒 包封率 载药量 

分 类 号：R96[医药卫生—药理学]