高原康胶囊对模拟高原缺氧大鼠颅内压的影响  

Effect of Gaoyuankang Capsules on intracranial pressure in simulated high-altitude hypoxia environment in rats

作　　者：孙创斌[1] 陶朝阳 王建军[1] 蒋海军[1] 李素芝[1] 

机构地区：[1]西藏军区总医院药物制剂研究中心,850007

出　　处：《高原医学杂志》2014年第4期5-7,共3页Journal of High Altitude Medicine

摘　　要：目的:探讨高原康胶囊在模拟高原缺氧条件下对大鼠颅内压的影响。方法:大鼠进入模拟海拔5 000m的高原低氧环境。实验分为5组:平原对照组、模拟高原对照组及高原康低、中、高三个剂量组。缺氧12h后,各组分别灌服相应药物,给药1.5h后,用直接插管法测定大鼠颅内压。结果:高原康胶囊可明显降低缺氧大鼠颅内压。结论:高原康胶囊具有降低缺氧大鼠颅内压的作用。Objective：To investigate the effect of Gaoyuankang Capsules on intracranial pressure in simulated high - altitude hypoxia condition in rats. Methods： Rats were fed in the simulated high - altitude 5 000meters hy- poxia environment. Rats were divided into 5 groups：the plain control group, the simulated high - altitude control group, and Gaoyuankang capsules groups （20mg/kg,40mg/kg,80mg/kg）. Each group rats were administrated with corresponding drugs after hypoxia for 12h, and the intracranial pressure of rats were determined after administration for 1.5h. Results：Gaoyuankang capsules can obviously reduce intracranial pressure in hypoxic rats. Conclusion： Gaoyuankang capsules have a role of reducing intracranial pressure in hypoxic rats.

关 键 词：高原康胶囊 模拟高原 缺氧 颅内压 

分 类 号：R965[医药卫生—药理学]