p38MAPK在糖尿病心肌病中的作用研究进展  

Research Progress in Role of p38 Mitogen-activated Protein Kinase in Diabetic Cardiomyopathy

作　　者：揭海 吴铿[1] 

机构地区：[1]广东医学院附属医院,广东湛江524001

出　　处：《中国医学创新》2015年第13期153-156,共4页Medical Innovation of China

基　　金：广东省重大科技专项项目(2012A080202020)

摘　　要：p38丝裂原活化蛋白激酶(p38 mitogen-activated protein kinase,p38MAPK)是丝裂原活化蛋白激酶(MAPK)信号系统的重要分支,是主要分布于细胞浆的一种丝氨酸/苏氨酸蛋白激酶,它在糖尿病心肌病(diabetic cardiomyopathy,DCM)发病中起重要作用,可被多种因素激活,在微血管病变、心肌间质纤维化、心肌肥厚、心肌凋亡中扮演着重要角色。深入研究p38MAPK在DCM中的分子机制,有助于阐明DCM发病机制,为防治DCM提供新靶点。p38 mitogen-activated protein kinase（p38MAPK）is an important member of the mitogen-activated protein kinase（MAPK）superfamily,which is mainly distributed in the cytoplasm and a serine/threonine kinase. It plays an important role in the pathogenesis of diabetic cardiomyopathy（DCM）,such as microvascular disease,myocardial fibrosis,cardiac hypertrophy,myocardial apoptosis and so on,which can be activated by a variety of factors. Studying the role of p38MAPK is helpful to further clarify the pathogenesis of DCM,as well as to provide new target for DCM treatment.

关 键 词：P38MAPK 糖尿病心肌病 微血管病变 心肌间质纤维化 心肌肥大 心肌凋亡 

分 类 号：R587.2[医药卫生—内分泌]