血清同型半胱氨酸与心脑血管疾病的相关性分析  

CORRELATIVE ANALYSIS OF SERUM HOMOCYSTEINE LEVELS AND CARDIOVASCULAR AND CEREBROVASCULAR DISEASES

作　　者：樊淑珍[1] 刘如 王美英[1] 刘儒[1] 

机构地区：[1]内蒙古医科大学附属医院检验科,内蒙古呼和浩特010050 [2]内蒙古军区第二干休所卫生所

出　　处：《内蒙古医科大学学报》2014年第5期428-431,共4页Journal of Inner Mongolia Medical University

基　　金：国家自然科学基金项目(81360109)

摘　　要：目的:探讨血清同型半胱氨酸(Hcy)与心脑血管疾病的关系。方法:测定152例冠心病病人,82例脑卒中病人和105例健康对照组血清同型半胱氨酸(Hcy)水平。结果:冠心病组和脑卒中组血清同型半胱氨酸(Hcy)水平分别为(21.35±9.78)μmol/L和(24.12±11.21)μmol/L,均明显高于健康对照组血清同型半胱氨酸(Hcy)水平(10.23±6.83)μmol/L,比较差异有统计学意义(P<0.01)。结论:血清同型半胱氨酸(Hcy)与心脑血管疾病病人有密切关系,高浓度的血清同型半胱氨酸(Hcy)是心脑血管疾病病人的独立的危险因子,降低同型半胱氨酸(Hcy)可以预防和减少动脉粥样硬化的发生,值得进一步研究。Objective：To investigate the relationship between serum homocysteine（ Hcy） and cardi-ovascular and cerebrovascular diseases. Methods：The serum Hcy levels were detected in 152 patients with coronary heart disease （ CHD ） , 82 patients with stroke and 105 healthy controls. Results：The average level of Hcy in the patients with CHD,stroke and healthy controls was（21. 35±9. 78）μmol/L、（24. 12±11. 21）μmol/L and（10. 23±6. 83）μmol/L,respectively,Hcy level in patients with CHD, stroke was significantly higher than that of the normal control group（P〈0. 01）. Conclusion：Serum Hcy is closely associated with cardiovascular and cerebrovascular diseases,high level Hcy is an independent risk factor of cardiovascular and cerebrovascular diseases,lowering homocysteine level can prevent and reduce the occurrence of atherosclerosis.

关 键 词：同型半胱氨酸 冠心病 脑卒中 

分 类 号：R541.2[医药卫生—心血管疾病]