辽东楤木叶总皂苷抗肿瘤作用研究进展  

Anti-tumor Reasearch Progress of Aralia eleta Total Saponins

作　　者：张秀萍[1] 孙达辰[1] 肖洪彬[2] 

机构地区：[1]牡丹江医学院,黑龙江牡丹江157011 [2]黑龙江中医药大学,哈尔滨150040

出　　处：《中国实验方剂学杂志》2015年第11期232-234,共3页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：国家自然科学基金面上项目(30772779);国家"重大新药创制"科技重大专项(2011ZX09102-001-18)

摘　　要：对辽东楤木叶总皂苷抗肿瘤的作用的研究已取得一定的进展,主要涉及人肺腺癌、人乳腺癌、小鼠腹水瘤相关细胞的体外移植瘤模型研究及人肝癌、人结肠癌、人胃癌、人卵巢癌、人红白血病细胞水平的研究。为了进一步了解辽东楤木叶总皂苷在抗肿瘤方面的研究现状并了解其抗肿瘤作用的效果,通过对比前人及课题组在肿瘤体外移植瘤模型制备时细胞密度、辽东楤木叶总皂苷使用剂量、使用时间及在细胞水平中辽东楤木叶总皂苷剂量使用情况,最终发现,辽楤木叶总皂苷达50 mg·kg-1时,即达到一定肿瘤抑制率;100 mg·kg-1时,可以有效抑制肿瘤组织中相关蛋白的表达;并通过抑制肿瘤大小及影响其形态学变化而有效抑制肿瘤的生长。其给药间隔时间及持续时间不同,对不同类型肿瘤模型的作用也有一定的差别。细胞研究时发现,不同浓度对不同细胞的增殖、凋亡有一定的作用,并对其蛋白表达有一定的影响。这些都为辽东楤木叶总皂苷抗肿瘤的药理作用及临床应用提供更可靠的实验依据。At present, the research on anti-tumor activity of the total saponins of Aralia eleta has made certain progress, which mainly related to transplantation tumor model of human lung adenocarcinoma, breast cancer, mouse ascites tumor in vitro and cell studies on human hepatocellular carcinoma, human colon cancer, gastric cancer, ovarian cancer and human erythroleukemia in vivo. In order to understand the research status of total saponin of Aralia eleta in anti-tumor activity, and investigate the anti-tumor effect, we compared our research to the previous research on cell concentration, the dose and the usage time of total saponins in tumor model in vitro and in vivo. Finally, we discovered that the total saponins were effective at a dosage of 50 mg·kg^-1 in vitro, and the different dose interval and duration have different effect. However, the different dose has different effect in vivo too. These researches provide the experimental basis for clinic application and pharmacological action for total saponins of Aralia eleta.

关 键 词：辽东楤木叶总皂苷 抗肿瘤作用 研究进展 

分 类 号：R287[医药卫生—中药学]