吡啶类化合物合成氯代吡啶的研究进展  

Research Advances in the Synthesis of Chloropyridines from Pyridines

作　　者：赵若含[1] 邬倩倩[1] 郑土才[1] 章梦帅 何金努 

机构地区：[1]衢州学院化学与材料工程学院,浙江衢州324000

出　　处：《化工生产与技术》2015年第2期23-29,52,共8页Chemical Production and Technology

基　　金：衢州市科技计划项目(2013Y001);浙江省大学生科技创新项目(2014R427001)

摘　　要：介绍了氯代吡啶化合物的用途,叙述了由吡啶类化合物经光氯化、高温氯化、亲电氯化、羟基置换氯化、硝基置换氯化、氨基的重氮化氯化、N-氧化物的转位氯化等方法合成氯代吡啶的研究进展,重点介绍了反应所用的氯化试剂等反应条件。指出国内外对氯化反应的研究仍不够深入,尤其较少考虑绿色化学理念;建议加强这些氯化反应的研究,并积极开发新反应方法、新型氯化剂,以及采用无溶剂反应、微波加热等新型反应方式等,并加强氯代吡啶类化合物的应用研究。This review first introduced the use of chloropyridines,then summarized recent advances in the synthesis of chloropyridines from pyridines via chlorination methods such as photo-chlorination, high-temperature chlorination, electrophilic chlorination,displacement chlorination of hydroxy groups and of nitro groups, diazotization chlorination of amino groups, and deoxygenative chlorination of N-oxides from the corresponding pyridine, with particular emphasis on the major reaction conditions such as chlorinating agents. Pointed out that the research on chlorination reaction were still not in-depth enough domestic and overseas,especially in green chemical concept less. The chlorination reaction research should be strengthened, and should actively develop new reaction method, new type chlorinating agent, and new reaction way such as solvent-free or microwave heating etc, and should strengthened the application research of chloropyridine compounds.

关 键 词：氯代吡啶 光氯化 亲电氯化 置换氯化 重氮化氯化 转位氯化 合成 

分 类 号：O626.32[理学—有机化学]