季膦离子液体促进的Morita-Baylis-Hillman反应  

Phosphonium Ionic Liquids-Accelerated Morita-Baylis-Hillman Reaction

作　　者：赵三虎[1,2] 王豆[2] 王敏[2] 康锦[1] 张立伟[1] 

机构地区：[1]山西大学分子科学研究,所太原030006 [2]忻州师范学院化学系,忻州034000

出　　处：《有机化学》2015年第4期865-874,共10页Chinese Journal of Organic Chemistry

基　　金：山西省重点学科基金(No.20141010);研究生创新项目(No.020352901016);忻州师范学院重点学科基金(No.XK201304)资助项目~~

摘　　要：膦类离子液体,因其好的热稳定性以及在弱碱性介质中的惰性等优异特点,正在受到越来越多的关注.以廉价的三丁基膦和各种卤代烃为原料,制备了一系列季膦离子液体,然后以其与水组成的复合体系为反应介质,在催化剂1,4-二氮杂二环[2.2.2]辛烷(DABCO)作用下,进行了各种醛与丙烯腈、丙烯酸甲酯及丙烯酰胺的Morita-Baylis-Hillman反应研究.实验结果表明,在室温条件下,溴化乙基三丁基膦与水组成的复合溶剂体系,有效地促进了各种芳香醛及脂肪醛的Morita-Baylis-Hillman反应,不仅反应速度快,而且目标产物产率高.Phosphonium ionic liquids, due to their superior thermal stability and an inertness in weak basic reaction media, are receiving more and more attention. A series of phosphonium ionic liquids have been prepared starting from cheap tribu- tylphosphine with various halogenated hydrocarbon. Then using 1,4-diazabicyclo[2.2.2]octane （DABCO） as catalyst and wa- ter-phosphonium ionic liquid composite system as reaction media, Morita-Baylis-Hillman reactions of a variety of aldehydes with acrylonitrile, methyl acrylate or acrylamide were studied. Experimental results showed that the composite system of phosphonium ionic liquid with water can effectivily accelerate the Morita-Baylis-Hillman reactions of aromatic aldehydes and aliphatic aldehydes, and fast reaction rate and high yield were obtained.

关 键 词：膦类离子液体 水 醛 Morita-Baylis-Hillman反应 

分 类 号：O621.251[理学—有机化学]