藤黄酸重排反应产物研究  

Research of Rearrangement Products of Gambogic Acid

作　　者：杨鑫[1] 孙中强[1] 邓云霞[1] 邵志宇[1] 

机构地区：[1]东华大学化学化工与生物工程学院,上海201620

出　　处：《有机化学》2015年第4期917-921,共5页Chinese Journal of Organic Chemistry

基　　金：中央高校基本科研业务费专项资金(Nos.13D110513;2232012D3-03)资助项目~~

摘　　要：藤黄酸能显著抑制多种人类肿瘤细胞的增殖,在酸性环境中易发生重排反应,其重排产物对肿瘤细胞也具有很强的抑制作用.通过波谱技术确定了两个藤黄酸的重排反应产物的结构并归属了其波谱数据.细胞毒活性测试显示,两个重排产物对A549,HCT116和MDA-MB-231显示很强的抑制作用.Gambogic acid derivatives possess potent anti-tumor activities against various cancer cell lines. In a search for new anti-tumor organic compounds, rearrangement reaction of gambogic acid was explored. Alter microwave irradiation under acidic condition, two rearrangement products were isolated and their structures were determined unambiguously by spectro- scopic techniques. Both of them were screened for their cytotoxicities against A549, HCT 116 and MDA-MB-231, and showed high inhibitory effects on the cell lines.

关 键 词：藤黄酸 重排反应 波谱技术 细胞毒活性 

分 类 号：O621.25[理学—有机化学]