川西獐牙菜活性成分对NO_2^-的清除作用研究  

Scavenging Effect of active chemical constituents From Swertia mussotii on NO_2^-

作　　者：罗翠婷[1,2] 江富祥[2] 陈河如[2] 

机构地区：[1]广东省湛江中医学校,广东湛江524094 [2]暨南大学药学院中药及天然药物研究所,广东广州510632

出　　处：《中国民族民间医药》2015年第10期22-24,共3页Chinese Journal of Ethnomedicine and Ethnopharmacy

摘　　要：目的:分析川西獐牙菜(Swertia mussotii Franch)的活性化学成分对亚硝基(NO2-)的清除作用,为寻找川西獐牙菜的防癌活性成分提供科学依据。方法:使用紫外分光光度法测定亚硝基的含量,根据活性追踪的结果筛选出对NO2-有较好的清除作用的口山酮类化合物。结果:川西獐牙菜乙醇提取物的正丁醇萃取部位对NO2-的清除率最高,并筛分出清除能力最好的化合物是7-羟基-3,4,8-三甲氧基-1-O-β-D-吡喃葡萄糖-口山酮苷。结论:川西獐牙菜清除NO2-的活性物质是一些极性较大的化合物,为进一步研究川西獐牙菜的防癌作用及相关产品的开发奠定了实验基础。Objective To analyze the scavenging effect of active chemica constituents from Swertia mussotii on NO 2 -,To provide a scientific basis for searching the anti -cancer active components from Swertia mussotii.Method the UV spectrophotometry was used to determine the NO 2 - content,screening out xanthone compounds with the effect to scavenge NO 2 - according to the active tracking results.Results The n -butanol fraction of the ethanol extracted of Swertia mussotii showed a highestscavenging rate,and 7 -hydroxy-3,4,8 -trimethoxy -1 -O -β-D -glucopyranosyl -xanthone is the best compounds from the Screening experiment.Conclu-sion The active substances with the effect to scavenge NO 2 - is high polar compounds in Swertia mussotii.This result should lay a the-oretical foundation for the further research on the cancer prevention of Swertia mussotii and development of the relevant products.

关 键 词：川西獐牙菜 NO 2 - 口山酮 防癌作用 

分 类 号：R284.2[医药卫生—中药学] R285.2[医药卫生—中医学]