在体单向肠灌流法研究细叶远志皂苷的大鼠肠吸收特性  

Research on the Intestinal Absorption of Tenuifolin in Rats by Single Pass Perfusion in Situ

作　　者：刘可[1] 刘利根[1] 富志军[1] 

机构地区：[1]中国药科大学中药制剂教研室,南京211198

出　　处：《海峡药学》2015年第4期18-20,共3页Strait Pharmaceutical Journal

摘　　要：目的研究细叶远志皂苷在大鼠四个肠段的吸收状况。方法运用大鼠在体单向肠灌流模型,采用重量法,研究细叶远志皂苷在不同肠段的吸收情况。结果在体小肠吸收实验中,细叶远志皂苷可被大鼠全肠段吸收,在十二指肠、空肠、回肠及结肠各肠段的药物吸收速率常数(Ka)分别是0.05922,0.06387,0.06345,0.06409s-1;药物表观吸收系数(Papp)分别是0.03322,0.03751,0.03733,0.04830cm·s-1,结肠段吸收最好(P<0.001)。结论细叶远志皂苷为全肠道吸收的药物,且结肠部位吸收最好。OBJECTIVE To study the absorption condition of tenuifolin in four intestine Segments in rats.METHODS In situ single pass perfusion model of rat was set up,taking gravimetry as a marker,the absorption of tenuifolin in small intestine was studied.RESULTS The tenuifolin could be absorbed in whole intestinal seg-ments.The absorption rate constants （ Ka ） of tenuifolin at duodenum, jejunum, ileum and colon was 0.05922,nbsp;0.06387,0.06345,0.06409s-1,respectively;the apparent permeability coefficients （Papp） was 0.03322,0.03751, 0.03733 ,0.04830 cm·s-1 .Ka and Papp at colon were significantly higher than that at the other regions of intestine （P〈0.001）.CONCLUSION Tenuifolin can be absorbed in the whole intes-tinal,especially in colon.

关 键 词：细叶远志皂苷 在体单向肠灌流 重量法 吸收部位 

分 类 号：R969[医药卫生—药理学]