曲尼司特抑制烧伤瘢痕增生的给药时间分析  

TRANILAST ADMINISTRATION TIME FOR SUPPRESSION OF BURN SCAR HYPERPLASY

作　　者：潘文妍[1,2] 

机构地区：[1]广西医科大学第四附属医院 [2]柳州市工人医院,广西柳州545005

出　　处：《现代医院》2015年第5期96-97,100,共3页Modern Hospitals

基　　金：广西自然科学基金(编号:2013GXNSFAA019260);广西医学科研基金(编号:Z2011491)

摘　　要：目的分析在烧伤创面开始修复和完全愈合后2个时间点口服曲尼司特抑制烧伤瘢痕增生的临床效果。方法将2011年7月~2013年12月间就诊的60例烧伤患者随机分为A组与B组,每组30例,分别于创面开始修复和完全愈合后2个时间点给予口服曲尼司特进行干预,比较两组治疗效果。结果在患者创面愈合后6个月应用温哥华瘢痕量表进行评价,结果显示两组治疗效果差异无统计学意义（p〉0.05）,均无不良反应发生。结论在烧伤创面开始修复和完全愈合后2个时间点口服曲尼司特干预,临床效果无明显差异。Objective To study the clinical effects of oral administration of tranilast to suppress burn scar hyperplasy when the burn wounds began repairing or were completely healed. Methods Sixty burn patients from July2011 to December 2013 were randomly divided into groups A and B,30 patients in each group. Thirty patients were treated with orally- administered tranilast at the beginning of wound repair,while the other patients were treated with orally administered tranilast when the burn wounds were completely healed. The therapeutic effect of these two groups was compared. Results Six months after burn wound healing,Vancouver scar scale was applied to evaluate the therapeutic effect. No significant differences were found between these two groups（ p 〉 0. 05）,and no adverse reactions were observed. Conclusion No significant differences in clinical effects of oral tranilast administered at the beginning of burn wound repair and at the time point of complete healing.

关 键 词：曲尼司特 烧伤 瘢痕增生 修复 愈合 

分 类 号：R644.01[医药卫生—外科学]