滇西地区10种植物抗疟活性研究  

Evaluation of Antimalarial Activity of the Ten Herbs from West Yunnan

作　　者：刘子琦[1,2] 肖朝江[1,2] 张小东[1,2] 徐伟[1,2] 彭俊霖 姜北[1,2] 

机构地区：[1]大理学院药物研究所,云南大理671000 [2]大理学院药学与化学学院,云南大理671000

出　　处：《大理学院学报（综合版）》2015年第4期1-4,共4页Journal of Dali University

基　　金：国家自然科学基金资助项目(81460532)

摘　　要：目的:研究10种采自滇西地区植物的抗疟活性,为从天然产物中寻找新的抗疟成分或先导化合物奠定基础。方法:将植物样品粉碎,依次用75%乙醇、水回流提取,提取物经冷冻干燥后,采用β-羟高铁血红素形成抑制试验进行筛选,以IC50值评价其活性。结果:在供试的10种植物样品中,梁王茶地下部分、球花报春花、糙毛杜鹃、西域蜡瓣花等4种植物粗提物具有不同程度的β-羟高铁血红素形成抑制活性,相关提取物的IC50值均大于1 388.9μg/m L。结论:梁王茶、球花报春花、糙毛杜鹃、西域蜡瓣花4种植物具有一定的抗疟活性,值得深入研究。Objective： To study the antimalarial activity of ten herbs collected from west Yunnan for the development of new generation of antimalarial drugs. Methods： After being milled, the plant materials were extracted three times under reflux with 75% ethanol and water successively. The extracts were completely dried using lyophilization, and the resulting samples were tested for the antimalarial activity by β-hematin inhibition screening assay. The activities were evaluated by IC50 values. Results： Four of the ten testing plants, Metapanax delavayi, Primula denticulate, Rhododendron trichocladum, and Corylopsis himalayana, showed moderate activity to inhibit β-hematin formation with the IC50 over 1 388.9 μg/mL. Conclusion： The four plants deserved to be further studied for their potential antimalarial activity.

关 键 词：抗疟活性 β-羟高铁血红素形成抑制试验 植物 滇西地区 粗提物 

分 类 号：R978.61[医药卫生—药品]