隔山消对小鼠小肠推进作用的研究  

Effect of the Extracts from Geranium strictipes R. Knuth on the Intestinal Propulsion Function in Mice

作　　者：耿玲[1,2] 李洪文 陈俊雅[2,4] 李辉[2,4] 

机构地区：[1]大理学院基础医学院,云南大理671000 [2]云南省昆虫生物医药研发重点实验室,云南大理671000 [3]楚雄医药高等专科学校,云南楚雄675000 [4]大理学院药学与化学学院,云南大理671000

出　　处：《大理学院学报（综合版）》2015年第4期5-7,共3页Journal of Dali University

基　　金：大理学院青年教师科研基金资助项目(KYQN201309)

摘　　要：目的:初步探讨隔山消乙酸乙酯提取物对小鼠小肠推进功能的影响。方法:对正常小鼠以及阿托品诱导的小肠功能抑制小鼠给予隔山消乙酸乙酯提取物,通过测定不同实验组炭末混悬液在小肠中的推进距离,评价隔山消乙酸乙酯提取物对小肠推进功能的影响。结果:隔山消乙酸乙酯提取物各剂量组均能明显提高正常小鼠小肠炭末推进率,其中高剂量组的作用最为明显,推进率达到了75.93%;隔山消乙酸乙酯提取物各剂量组还能提高阿托品抑制的小鼠小肠炭末推进率,以低剂量作用最好,推进率达到了43.28%。结论:隔山消乙酸乙酯提取物可以明显促进小肠运动,并能对抗阿托品所致的小鼠小肠功能障碍,这可能与M胆碱受体有关。Objective： To study the effect of the ethyl acetate extract from Geranium strictipes R. Knuth （EAEG） on the intestinal propulsion function in mice. Methods： Normal mice and mice of intestinal function inhibited by atropine were given different doses EAEG for continuous 4 days, finally the propulsion distance of carbon in intestinal was measured. Results： EAEG-L （50 mg/kg）, EAEG-M （100 mg/kg） and EAEG-H （200 mg/kg） all could increase the propulsion rate in normal mice, even the figure is up to 75.93% in EAEG-H group; in addition, EAEG-L （50 mg/kg）could improve apparently intestinal carbon propulsion rate which is 43.28%. Compared with control group, the difference is statistically significant. Conclusion： The acceleration of EGEG on intestinal movement in normal mice and mice intestinal-inhibited by atropine may be related with M receptor.

关 键 词：隔山消乙酸乙酯提取物 小肠推进 炭末 阿托品 

分 类 号：R284.3[医药卫生—中药学]