紫地榆的乙酸乙酯部分和水部分抗粘性放线菌的体外研究  

Antibacterial Activities of the Ethyl Acetate Part and the Water Part of Geranium Trictipes R. Kunth to Actinomyces Viscosus in Vitro

作　　者：杨淋[1] 王涛[2] 蓝海[1] 

机构地区：[1]大理学院药学与化学学院,云南大理671000 [2]大理学院基础医学院,云南大理671000

出　　处：《大理学院学报（综合版）》2015年第4期8-11,共4页Journal of Dali University

基　　金：国家自然科学基金资助项目(81260512);云南省大理学院应用开发研究基金资助项目(kyyy201102)

摘　　要：目的:研究紫地榆乙酸乙酯部分和水部分对粘性放线菌生长、产酸及粘附的影响。方法:首先测定紫地榆乙酸乙酯部分和水部分对粘性放线菌最低抑菌浓度(MIC),再以低于MIC的4个浓度配制含药的TPY液体培养基测定紫地榆乙酸乙酯部分和水部分对粘性放线菌最低杀菌浓度(MBC)、产酸及粘附的影响。结果:紫地榆乙酸乙酯部分和水部分对粘性放线菌的最低抑菌浓度(MIC)分别为4.500 g/L、9.000 g/L,最低杀菌浓度(MBC)分别为9.000 g/L、18.000 g/L;一定浓度的紫地榆乙酸乙酯部分和水部分对粘性放线菌的产酸和粘附有一定的抑制作用。结论:紫地榆有可能是一种潜在的天然防龋药物,值得进行更深入的研究。Objective： To investigate the effect of the ethyl acetate part and the water Part of Geranium strictipes R. Kunth on the growth, acidogenicity, adhesion of Actinomyces viscosus （A.v）. Methods： Aetinomyces viscosus was chosen as the experimental bacteria. And then the effects of the ethyl acetate part and the water portion of G. strictipes on the growth （including the minimum inhibitory concentration and the minimum bactericidal concentration）, acid generation and adhesion were assessed. Results： The MIC of the ethyl acetate part and the water portion of G. strictipes against A.v was 4.500 g/L ,9.000 g/L, the MBC of the ethyl acetate part and the water Part of G. strictipes against A,v was 9.000 g/L ,18.000 g/L; it was found that the ethyl acetate part and the water Part of G. strictipes can inhibit the acid generation and adhesion of the A,v effectively. Conclusion： The ethyl acetate part and the water Part of G, strictipes may be an effective anti-caries agent.

关 键 词：紫地榆 萃取物 粘性放线菌 生长 产酸 粘附 

分 类 号：R285.5[医药卫生—中药学]