肝龙胶囊及美洲大蠊脱脂膏对小鼠急性结肠炎的影响  

Effects of Ganlong Capsule and Periplaneta americana Skim Cream on Acute Colitis in Mice

作　　者：牛春丽[1] 曾菁[1] 夏盟恺 彭芳[1] 

机构地区：[1]大理学院药学与化学学院,云南大理671000

出　　处：《大理学院学报（综合版）》2015年第4期12-16,共5页Journal of Dali University

摘　　要：目的:初步探讨肝龙胶囊及美洲大蠊脱脂膏对小鼠急性结肠炎的作用及可能的作用机制。方法:采用DSS造模法,通过测定小鼠的DAI并检测结肠组织的MPO含量和观察结肠组织TNF-α免疫组化表达来评价肝龙胶囊及美洲大蠊脱脂膏对急性结肠炎的影响。结果:肝龙胶囊及美洲大蠊脱脂膏能够减轻小鼠急性结肠炎的炎性因子的浸润、减少粘膜出血溃疡、降低TNF-α表达、腺体消失等现象并降低结肠组织中的MPO含量(P<0.05)。结论:肝龙胶囊及美洲大蠊脱脂膏对DSS所致的小鼠急性结肠炎有很好的保护作用。Objective： To study the effect of Ganlong capsule and Periplaneta americana skim cream on acute colitis in mice and to further observe the mechanism of action. Methods： The experiment uses the DSS modeling method to evaluate the effects of Ganlong capsule and P. americana skim cream on acute colitis through the MPO content and the observation of colon tissue TNF-α immunohistochemical and detection of mice colon tissue of calculation of DAI. Results： Ganlong capsule and P. americana skim cream can reduce infiltration of inflammatory cytokines, reduce mucosal bleeding ulcer, glands disappeared, reduce the expression of TNF-α, the Ganlong capsule groups and P. americana skim cream groups can reduce the content of MPO in the colonic tissues （P 〈 0.05）. Conclusion： Ganlong capsule and P. americana skim cream have very good protection effect on acute colitis induced by DSS.

关 键 词：美洲大蠊 肝龙胶囊 急性结肠炎 

分 类 号：R752.11[医药卫生—皮肤病学与性病学]