腹型肥胖中青年男性早期糖代谢改变与体成分的相关性分析  被引量:2

Relationship Between Early Change of Glucose Metabolism and Body Composition in Young and Middle-age Abdominal Obese Males

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作  者:刘晓丽[1] 马春朋[1] 尹福在[1] 高国芹[1] 马春明[1] 王锐[1] 陆强[1] 

机构地区:[1]河北省秦皇岛市第一医院,河北秦皇岛066000

出  处:《医学临床研究》2015年第4期742-744,共3页Journal of Clinical Research

摘  要:【目的】探讨糖耐量正常(NGT )的腹型肥胖中青年男性糖耐量试验变化与体成分的关系。【方法】选择2009年在本院体检中心进行体检的67例NGT 成年男性,年龄20~50岁,根据腰围(WC)将其分为两组:WC正常成年男性组(对照组,n =31),腹型肥胖成年男性组(研究组,n =36)。两组研究对象均进行口服葡萄糖耐量试验(OGTT),并检测其空腹血糖(FPG),糖负荷后0.5 h血糖(0.5hPG)、1hPG、2hPG、3hPG。应用双能X线骨密度仪进行体成分分析。【结果】两组间FPG、2hPG、3hPG比较无统计学差异( P >0.05),研究组0.5hPG ,1hPG和葡萄糖曲线下面积(AUCglu )高于对照组( P <0.05)。体质量指数(BMI),WC及各部位脂肪质量与FPG及3hPG无相关性( P >0.05);0.5hPG、2hPG与总体脂肪质量及躯干脂肪质量存在正相关( P <0.05)。1hPG 及AUCglu与BMI ,WC ,总体脂肪质量,四肢脂肪质量,躯干脂肪质量均呈正相关( P<0.01)。【结论】糖耐量正常腹型肥胖中青年男性已存在糖负荷后血糖代谢异常,与BMI和WC相比,体脂成分分析更能有效识别肥胖男性早期糖代谢异常。[Objective] To explore the relationship between the changes of oral glucose tolerance test and body composition in young and middle‐age abdominal obese males with normal glucose tolerance (NGT ) .[Methods] This case‐control study included 36 abdominal obese males (waist circumference ,WC≥90 cm) and 31 non‐abdominal obese males (WC〈 90 cm) aged 20~50 years with NGT .Both cases and controls were matched in age .Body fat content was measured by dual‐energy X‐ray absorptiometry .[Results]Fasting plasma glucose ,2 and 3‐hour postload plasma glucose were similar in two groups ( P 〉0 .05) .0 .5 ,1‐hour postload plasma glucose (1hPG) and glucose area under the curve (AUCglu ) were higher in abdominal obese group than those in control group ( P〈0 .05) .AUCglu was positively correlated with body mass index ( r =0 .390) ,WC ( r =0 .438) ,total body fat content ( r =0 .445) ,limbs fat content ( r =0 .372) and trunk fat content ( r =0 .475)( P 〈0 .01) .According to multiple regression analysis ,trunk fat content was an independent predictor for AUCglu (β=3 .332 ,P=0 .000 ,R2 =0 .228) .[Conclusion] The changes of postload plasma glucose occur in young and middle‐age abdominal obese males with NGT .Body composition assessment is a valid and more ac‐curate method than BMI and WC for predicting early changes of glucose metabolism .

关 键 词:肥胖症/代谢 人体质量指数 血糖/分析 脂类/分析 

分 类 号:R589.25[医药卫生—内分泌]

 

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