鳖甲丹红化纤方治疗慢性肝炎肝纤维化临床研究  

Clinical Curative Effect of Biejia Danhong Huaxian Prescription Treatment of Hepatitis Liver Liber

作　　者：蔡庆春 王红玲 蒋士卿[2] 

机构地区：[1]河南中医学第三附属医院,河南郑州450008 [2]河南中医学院,河南郑州450046

出　　处：《中医学报》2015年第5期728-730,共3页Acta Chinese Medicine

基　　金：河南省中医药科学研究专项课题(2013ZY02041)

摘　　要：目的:观察自拟鳖甲丹红化纤方治疗慢性肝炎肝纤维化的临床疗效及对肝纤维化血清标志物的影响。方法:90例慢性肝炎肝纤维化患者随机分为治疗组和对照组各45例,两组均给予护肝降酶等常规治疗,治疗组在常规治疗上加自拟鳖甲丹红化纤方。对照组在基础常规治疗上加重组干扰素α-2α50×106U,肌肉注射,每两日1次。8周为1个疗程,6个疗程后观察疗效。结果:治疗后两组丙氨酸氨基转移酶、天冬氨酸氨基转移酶、血清胆红素较治疗前明显降低(P<0.05),且治疗组低于对照组(P<0.01),治疗后两组血清白蛋白、血清球蛋白变化不明显,差异无统计学意义(P>0.05);两组透明质酸、层黏连蛋白、Ⅲ型前胶原及IV型胶原均较治疗前降低,且治疗组下降幅度大于对照组,差异有统计学意义(P<0.05);两组肝脏回声、门静脉内径、脾静脉内径、脾脏厚度均有减轻,但治疗组较为明显,差异有统计学意义(P<0.05);治疗组有效率为91.11%,对照组为73.33%,差异有统计学意义(P<0.01)。结论:自拟鳖甲丹红化纤方能抑制肝炎肝纤维化,改善肝功能,对肝炎肝纤维化有良好的临床疗效。Objective：To discuss the clinical curative effect of Biejia Danhong Huaxian Prescription treatment of hepatitis liver fiber and its influence on serum liver fibrosis markers.Methods：90 patients were randomly divided into treatment group and control group,each of 45 cases.Two groups both were given conventional treatment such as protecting liver and lowering enzyme,and the treatment group was given additionally self-made Biejia Danhong Huaxian Prescription.The control group on the basis of conventional treatment with recom-binant interferonα-2α5 million units,intramuscular,once every two days.After a course of 8 weeks,6 course of treatment.Results：Two groups after treatment of ALT,AST,TBiL,significantly lower than before treatment （P〈0.05）,and the treatment group was lower than the control group（P〈0.01）,the two groups after treatment does not change significantly propagated,GLB,there was no statistically sig-nificant difference （P〉0.05）;two groups of HA,LN,PC Ⅲ and IV-C was reduced and the and the treatment group decreased more than the control group,the difference was statistically significant （P〈0.05）;two groups of liver echo,portal vein diameter,inner diam-eter and thickness of the spleen and spleen vein with ease,but the treatment group is more obvious,the difference was statistically sig-nificant;The treatment group total effectiveness 91.11%,control group was 73.33%,the difference was statistically significant（P〈0. 01）;Conclusion：Self-made Biejia Danhong Huaxian Prescription can restrain hepatitis liver fibrosis,improve liver meritorious serv-ice,which has good clinical curative effect on hepatitis liver fibrosis.

关 键 词：慢性肝炎肝纤维化 鳖甲丹红化纤方 血清标志物 肝功能 

分 类 号：R259.752[医药卫生—中西医结合]