红芪多糖对12周龄糖尿病db/db小鼠血脂的影响  

Effect of Hedysarum Polybotys Saccharide on Blood Lipid of 12 Weeks Diabetic db / db Mice

作　　者：郑丽红[1] 金智生[2] 王海强[3] 魏玉娇[2] 朱真灵 关雁[2] 齐雪艳[2] 

机构地区：[1]黑龙江中医药大学附属二院,黑龙江哈尔滨150001 [2]甘肃中医学院,甘肃兰州730000 [3]黑龙江中医药大学附属一院,黑龙江哈尔滨150040

出　　处：《辽宁中医杂志》2015年第5期1125-1127,共3页Liaoning Journal of Traditional Chinese Medicine

基　　金：国家自然基金(81160427)

摘　　要：目的:观察红芪多糖对12周龄糖尿病db/db小鼠血脂、血糖的影响,以进一步评价红芪多糖对2型糖尿病糖脂代谢紊乱的调节作用。方法:将40只12周龄雄性SPF级BKS背景肥胖型2型糖尿病db/db小鼠随机分为红芪多糖(HPS)高剂量组、HPS中剂量组、HPS低剂量和模型对照组,每组10只;另外10只同品系非糖尿病db小鼠为正常对照组。分别给予红芪多糖及生理盐水灌胃治疗8周后观察各组小鼠的血脂情况。结果:红芪多糖高、中剂量组能明显改善db/db小鼠血脂水平(P<0.01),而红芪多糖低剂量组与模型组比较未见明显差异(P>0.05);在实验过程中,除正常对照组外,其余各组血糖均不同程度上升,治疗8周时,HPS高剂量组与模型组比较差异有统计学意义(P<0.05)。结论:红芪多糖对12周龄的db小鼠血脂、血糖有一定的调节作用,对研究血脂与2型糖尿病、肥胖、脂肪肝的关系及治疗有一定意义。Objective ：To observe the effect of Hedysarum Polybotys Saccharide on blood lipid and blood glucose of 12 weeks old diabetic db/db mice,in order to further evaluate the regulatory effect of Hedysarum Polybotys Saccharide on glucose and lipid metabolism disorder in type 2 diabetes mellitus. Methods ：40 db/db mice of 12 weeks old male SPF grade BKS background obesity and type 2 diabetes mellitus were randomly divided into Hedysarum Polybotys Saccharide （HPS） high dose group, middle dose group,low dose group and model group, 10 mice in each group;another 10 syngeneic non diabetic db mice as normal control group. Lipids were observed after treated with Hedysarum Polybotys Saccharide and physiological saline for 8 weeks. Results： Hedysarum Polybotys Saccharide high medium dose groups can obviously improve the blood lipid levels in db/db mice （P 〈 0. 01 ）, compared with the model group, no significant difference was found in the Hedysarum Polybotys Saccharide low dose group （ P 〉 0.05 ） ; during the experiment, except normal control group, the blood glucose of the rest groups increased in different degrees after 8 weeks, there was significant difference between the HPS of high dose group and model group （ P 〈 0. 05 ）. Conclusion ： Hedysarum Polybotys Saccharide has a role in regulating the blood lipids and blood glucose in db mice aged 12 weeks with type 2 diabetes,these may have certain significance in studying the relationship between blood lipids and obesity,type 2 diabetes,fatty liver and treatment.

关 键 词：红芪多糖 糖尿病 DB/DB小鼠 血脂 

分 类 号：R285.5[医药卫生—中药学]