祛痰散结方药干预冠心病痰浊壅塞证的机制研究  

Research on Meachanism of Qutan Sanjie Prescription Interventing Coronary Heart Disease of Phlegm Turbidity Congestion Syndrom

作　　者：李航[1] 李建锋[1] 赵启韬[2] 

机构地区：[1]山东中医药大学药学院,山东济南250355 [2]山东中医药大学基础医学院,山东济南250355

出　　处：《辽宁中医杂志》2015年第5期1129-1131,共3页Liaoning Journal of Traditional Chinese Medicine

基　　金：国家自然科学基金资助项目(81173164)

摘　　要：痰浊壅塞证是目前冠心病的主要证型及危险证型,和其他证型相比,患者血脂代谢紊乱程度、体内氧化应激状态异常程度、血管内皮功能损伤程度均最为严重。祛痰散结经典方药,包括瓜蒌薤白半夏汤、瓜蒌薤白白酒汤以及方中单味药,不仅对多种原因导致的心肌缺血、心肌缺血再灌注干预效果显著;尤其对冠心病(CHD)痰浊壅塞证表现出了独特的,更为显著的疗效。针对该病证的特点,本文阐述了上述方药的药理作用及其机制,如降血脂、逆转异常的氧化应激状态、修复内皮功能等,期望能启发对祛痰散结经典方药深入研发的新思路。At present, phlegm turbidity congestion syndrome is the main and hazardous traditional Chinese medicine （TCM） syndrome of coronary heart disease （CHD）. Compared with other TCM syndromes, both of the degree of blood lipid metabolic dis- turbance in patients and the degree of abnormal oxidative stress state in the body and the injury degree of endothelial function are the worst. The classical of Qutan Sanjie Fang, such as Gualou Xiebai Banxia Decoction, Gualou Xiebai Baijiu Decoction and the single herb in formulae, not only for myocardial ischemia, myocardial ischemia - reperfusion leaded by various reasons present ob- vious intervention effect,but also especially for CHD phlegm turbidity congestion syndrome showed the unique and more remarka- ble curative effect. According to characteristics of the disease syndrome, this paper expounds the pharmacological effects of the formulae and its mechanism, such as reducing blood lipid, reversing the abnormal state of oxidative stress, repairing endothelial function, ere, expecting to inspire new ideas of in - depth research on the classical formulas of expectorant fights.

关 键 词：冠心病痰浊壅塞证 脂类代谢 内皮功能 氧化应激 辨证论治 

分 类 号：R541.4[医药卫生—心血管疾病]