咪唑啉受体及其激动剂和拮抗剂的研究进展  

Research progress on imidazoline receptor and its agonists and antagonists

作　　者：潘伟男 邓水秀 

机构地区：[1]湖南食品药品职业学院药学系,长沙410208

出　　处：《实用药物与临床》2015年第5期603-606,共4页Practical Pharmacy and Clinical Remedies

摘　　要：咪唑啉受体不仅与血压调节、胰岛素分泌、神经元保护、肾脏排钠利尿、促进细胞增殖等重要生理功能相关,还参与了抑郁症、帕金森病、海洛因成瘾、亨廷顿舞蹈病、阿尔茨海默病等多种精神神经疾病的发生过程。本文就咪唑啉受体的生物学特征及其激动剂和拮抗剂的研究进展做一综述。Imidazoline receptor （IR） is not only associated with important physiological functions including blood pressure regulation,insulin secretion,neuron protection,renal natriuresis and promoting cell proliferation,but also involved in the neurological and psychiatric disorders such as depression,Parkinson′s disease,heroin addiction,Hunting-ton′s disease and Alzheimer′s disease. This paper summarizes the research progress on the biological characteristics of IR and its agonists and antagonists.

关 键 词：咪唑啉受体 利美尼定 莫索尼定 咪唑克生 依法克生 

分 类 号：R972[医药卫生—药品]