西格列汀对初发2型糖尿病患者胰岛B细胞功能的影响  

Effect of sitagliptin on pancreatic B cell function in the treatment of newly diagnosed type 2 diabetes

作　　者：卓凤婷[1] 张丽婷[1] 高旭航 

机构地区：[1]中国人民解放军第180医院内分泌科,福建泉州362000

出　　处：《实用药物与临床》2015年第5期622-624,共3页Practical Pharmacy and Clinical Remedies

摘　　要：目的研究西格列汀对初发2型糖尿病患者胰岛B细胞功能的影响。方法选择我院门诊2型糖尿病患者69例,随机分为对照组和试验组,对照组35例,试验组34例,对照组予二甲双胍治疗,试验组予二甲双胍、西格列汀治疗,12周后比较治疗前后两组患者空腹血糖(FPG)、餐后2 h血糖(PPG)、糖化血红蛋白(Hb A1c)、体重指数(BMI)、空腹胰岛素(Fins)、餐后2 h胰岛素(Pins)。结果两组治疗前各项指标比较差异无统计学意义(P>0.05),治疗后,两组FPG、PPG、Hb A1c、BMI均较治疗前显著下降(P<0.05)。与对照组相比,试验组FPG、PPG、Hb A1c降低更明显(P<0.05),Fins、Pins水平升高更显著(P<0.05)。结论西格列汀能明显改善初发2型糖尿病患者的胰岛B细胞功能,在临床应用中安全有效。Objective To explore the effect of sitagliptin on B cell function in the treatment of newly diag-nosed type 2 diabetes. Methods 69 outpatients with type 2 diabetes in our hospital were randomly divided into control group （n=35） and trial group （n=34）,patients were treated with metformin without or with sitagliptin respectively. Two groups were followed up for 12 weeks. Fasting plasma glucose （ FPG） ,2 h postprandial plasma glucose （ PPG） , glycosylated hemoglobin （HbA1c）,change in body mass index （BMI）,fasting plasma insulin （Fins）,2 h postprandial plasma insulin （ Pins） were recorded in the two groups before and after treatment. Results There was no significant difference between the two groups in FPG,PPG,HbA1c,BMI,Fins,Pins before treatment （P〉0. 05）. Compared with the baseline,FPG,PPG,HbA1c,BMI in both two groups declined significantly （P 〈0. 05）. After treatment,FPG, PPG,HbA1c were significantly lower,and Fins,Pins were significantly higher in treatment group compared with those in control group （P〈0. 05）. Conclusion Sitagliptin could obviously improve B cell function in the treatment of new-ly diagnosed type 2 diabetes,it is safe and effective in clinical application.

关 键 词：2型糖尿病 西格列汀 二肽基肽酶抑制剂 B细胞 

分 类 号：R587.1[医药卫生—内分泌]