血浆(1,3)-β-D葡聚糖检测对侵袭性真菌病的诊断意义  

Diagnostic significance of plasma( 1,3)-β-D glucan for invasive fungal disease

作　　者：唐红梅[1] 周吕蒙 赵兰兰[1] 李艳[1] 罗俊[1] 王婷婷[1] 徐煜[1] 蔡礼欢 郑勇[1] 

机构地区：[1]四川省攀枝花市攀钢集团总医院呼吸内科,四川攀枝花617023

出　　处：《安徽医药》2015年第5期927-929,共3页Anhui Medical and Pharmaceutical Journal

摘　　要：目的探讨血浆(1,3)-β-D葡聚糖检测对侵袭性真菌病的早期诊断意义。方法通过回顾性分析105例怀疑侵袭性真菌病的住院患者的血浆(1,3)-β-D葡聚糖含量和真菌培养结果,分别计算两种方法的阳性率及灵敏度、特异度、阳性和阴性预测值。结果侵袭性真菌病患者的血浆(1,3)-β-D葡聚糖检测阳性率和真菌培养阳性率分别是为80.00%和66.67%,两组差异有统计学意义(P<0.05);血浆(1,3)-β-D葡聚糖检测阳性者血浆(1,3)-β-D葡聚糖含量为(62.0±21.34)ng·L-1,阴性者为(5.1±2.03)ng·L-1,两组差异有统计学意义(P<0.05);葡聚糖检测灵敏度和特异度为80.0%和91.7%,葡聚糖检测的阳性预测值和阴性预测值分别为87.8%和85.9%,均较真菌培养高。结论血浆(1,3)-β-D葡聚糖检测方法快速、阳性率高、灵敏度和特异度高,可用于侵袭性真菌病的早期诊断。Objective We study the early diagnostic significance of plasma （1,3）-β-D glucan in patients with invasive fungal disease. Methods We retrospectively analyzed the plasma levels of （1 ,3 ）-β-D glucan and the results of fungal culture in 45 inpatients with invasive fungal disease and 60 inpatients with non-invasive fungal disease,calculating the positive rate,sensitivity,specificity,positive and negative predictive values of two methods,respectively.Results The positive rates of plasma （1 ,3 ）-β-D glucan and fungal cul-ture in the inpatients with invasive fungal disease were 80.00% and 66.67%,respectively,and the difference of two methods is significant （P〈0.05）.The plasma concentration of （1,3）-β-D glucan in positive samples was （62.0 ±21.34）ng·L -1 and in negative samples （5.1 ±2.03）ng·L -1,and the difference of two groups is significant （P〈0.05）.The sensitivity and spe-cificity of plasma （1,3）-β-D glucan were 80.0% and 91.7%,respectively,and its positive and negative predictive values were 87 .8% and 85 .9%,respectively,and all of them were higher than the values of fungal culture.Conclusions Because the detec-ting method of plasma （1,3）-β-D glucan is with rapidity,high positive rate,high sensitivity and specificity,it can be used for the early diagnosis of invasive fungal disease.

关 键 词：(1 3)-β-D葡聚糖 真菌培养 侵袭性真菌病 

分 类 号：R519[医药卫生—内科学]