二氧化碳激光术结合干扰素局部封闭治疗尖锐湿疣的临床研究  

Study of laser surgery combined with partial closure of interferon in treating genital warts

作　　者：周利敏[1] 王燕[1] 李红英[1] 胡瑞华[1] 雷燕[1] 张敦兰[1] 邹晓燕[1] 

机构地区：[1]湖北省妇幼保健院妇科,武汉430070

出　　处：《中国性科学》2015年第5期63-65,共3页Chinese Journal of Human Sexuality

摘　　要：目的:探究分析激光术后结合干扰素局部封闭治疗尖锐湿疣患者的临床疗效。方法:选择2011年3月至2013年7月来我院诊治的80例尖锐湿疣患者,按照随机数字表法分为实验组和对照组,每组患者40例。对照组患者只采取CO2激光治疗,实验组患者在对照组治疗基础之上结合利分能干扰素治疗。观察两组患者治疗前后IL-2、IL-10以及IL-4等炎症因子水平的变化;比较两组患者的临床治疗效果。结果:治疗前,实验组患者IL-2、IL-10以及IL-4的水平与对照组患者比较无显著性差异(P>0.05);经过治疗,实验组患者的IL-2水平显著升高,IL-10以及IL-4的水平显著降低,均较对照组患者变化大,具有统计学意义(P<0.05),且实验组患者的三项指标的治疗前后的差值均较对照组患者大,具有显著性差异(P<0.05);经过治疗,实验组患者的总有效率为97.5%,较对照组患者高,差异性比较明显(P<0.05)。结论:激光术后结合干扰素局部封闭治疗尖锐湿疣患者,能够显著改变患者外周血清炎症因子的水平,明显提高临床疗效,是一种值得推广的治疗方法。Objectives：To explore the clinical efficacy of laser surgery combined with partial closure of in-terferon in treating patients with genital warts.Methods：80 patients with genital warts in our hospital from March 2011 to July 2013 were selected and randomly divided into experimental group and control group,each group of 40 patients.Patients in the control group received only carbon dioxide laser treatment,while patients in the experimen-tal group received combined therapy of interferon therapy.Changes in the IL -2,IL -10 and IL -4 levels of in-flammatory cytokines of the two groups’patients before and after were observed;and the clinical outcomes were compared.Results：Before treatment,difference in IL -2,IL -10 and IL -4 between the two groups was not sig-nificant （P 〉0.05）;after treatment,IL -2 levels in the experimental group significantly increased,and the level of IL -10 and IL -4 was significantly reduced,with statistical significant difference between the two groups （P 〈0.05）;changes in the three indicators of patients in the experimental group was significantly larger than that in the control group （P 〈0.05）;after treatment,the total effective rate of the experimental group were 97.5%,higher than that of the control group,with significant difference （P 〈0.05）.Conclusion：Laser surgery combined with partial closure of interferon therapy can significantly change the level of inflammatory cytokines in peripheral blood of patients,significantly improve the clinical efficacy,which is worthy of promotion.

关 键 词：尖锐湿疣 激光术 干扰素 临床疗效 

分 类 号：R752.53[医药卫生—皮肤病学与性病学]