Polypeptide Brushes Grown via Surface-initiated Ring-opening Polymerization of α-Amino Acid N-Carboxyanhydrides  

作　　者：Yong Shen 李志波 Harm-Anton Klok 

机构地区：[1]Laboratory of Polymer Physics and Chemistry, Institute of Chemistry, Chinese Academy of Sciences [2]School of Polymer Science and Engineering, Qingdao University of Science and Technology [3]cole Polytechnique Fédérale de Lausanne (EPFL), Institut des Matériaux and Institut des Sciences et Ingénierie Chimiques, Laboratoire des Polymères, Batiment MXD, Station 12, CH-1015 Lausanne, Switzerland

出　　处：《Chinese Journal of Polymer Science》2015年第7期931-931,932-946,共16页高分子科学（英文版）

基　　金：financially supported by the Sino-Swiss Science and Technology Cooperation(No.EG41-092011)as well as the Chinese Academy of Sciences(Visiting Professorship for Senior International Scientists to H.A.K.)

摘　　要：Polypeptide brushes are attractive platforms to generate functional and responsive interfaces that are of potential interest due to their possible biodegradability, biocompatibility and tunable secondary structures. Surface-initiated ringopening polymerization（SI-ROP） of α-amino acid N-carboxyanhydrides represents a powerful and versatile strategy to generate polypeptide brushes. This review is an attempt to capture the state-of-the-art in this field and highlights the latest developments in several selected areas. In addition to presenting an overview of the synthetic methods that have been used to generate polypeptide brushes via SI-ROP, this article will discuss the preparation of patterned polypeptide brushes, the conformational properties of surface-tethered polypeptides, ways to control chain orientation at surfaces as well as properties and applications of these thin polymer films.Polypeptide brushes are attractive platforms to generate functional and responsive interfaces that are of potential interest due to their possible biodegradability, biocompatibility and tunable secondary structures. Surface-initiated ringopening polymerization（SI-ROP） of α-amino acid N-carboxyanhydrides represents a powerful and versatile strategy to generate polypeptide brushes. This review is an attempt to capture the state-of-the-art in this field and highlights the latest developments in several selected areas. In addition to presenting an overview of the synthetic methods that have been used to generate polypeptide brushes via SI-ROP, this article will discuss the preparation of patterned polypeptide brushes, the conformational properties of surface-tethered polypeptides, ways to control chain orientation at surfaces as well as properties and applications of these thin polymer films.

关 键 词：Polypeptide brushes Surface α-Amino acid N-carboxyanhydrides Ring-opening polymerization Secondary structure 

分 类 号：O631.5[理学—高分子化学]