PHB及mPEG-PHB嵌段共聚物的合成与表征  

Synthesis and Characterization of PHB and Block Copolymer mPEG-PHB

作　　者：李雪梅[1] 贺继东[1] 代元坤 张晶晶[1] 戎佳萌 

机构地区：[1]青岛科技大学橡塑材料与工程教育部重点实验室山东省橡塑材料与工程重点实验室,山东青岛266042

出　　处：《化学与生物工程》2015年第5期43-47,共5页Chemistry & Bioengineering

摘　　要：以β-丁内酯(BL)为单体、萘钾-冠醚为引发剂通过阴离子开环聚合合成聚(β-丁内酯)(PHB),研究了反应时间对PHB分子量的影响。在萘钾-冠醚引发体系的基础上制备聚乙二醇甲醚-钾大分子引发剂(mPEG-K),采用mPEGK引发β-丁内酯开环聚合合成两亲性嵌段共聚物聚乙二醇甲醚-聚(β-丁内酯)(mPEG-PHB),并通过1 HNMR、FTIR、DSC对其进行表征。通过分子自组装技术制备了mPEG-PHB共聚物的纳米粒子,采用SEM、TEM、DLS对纳米粒子进行表征。结果表明,在一定时间内PHB的分子量随反应时间的延长而增大。DSC结果表明,无定形的PHB明显降低了结晶性mPEG的结晶能力。mPEG-PHB纳米粒子为粒径在100nm左右的具有核壳结构的纳米微球。Usingβ-butyrolactone（BL）as monomer,naphthalene potassium-crown ether as initiator,poly（β-butyrolactone）（PHB）was synthesized by anionic ring-opening polymerization.The effect of reaction time on molecular weight of PHB was studied.Poly（ethylene glycol）methyl ether-potassium macroinitiators（mPEG-K） was synthesized based on naphthalene potassium-crown ether.Amphiphilic poly（ethylene glycol）methyl ether-poly（β-butyrolactone）（mPEG-PHB）was prepared by ring-opening polymerization of BL initiated by mPEG-K. Copolymer was characterized by 1 HNMR,FTIR,DSC.The copolymer nanoparticles were prepared by the mo-lecular self-assemble technology.These nanoparticles were characterized by SEM,TEM,DLS.The results showed that the molecular weight of PHB increased with reaction time in a certain time.The DSC results showed that amorphous PHB reduced the crystallization ability of mPEG significantly.These nanoparticles were core-shell structure nanospheres with size of 100 nm.

关 键 词：β-丁内酯 阴离子聚合 聚乙二醇甲醚 两亲性 纳米微球 

分 类 号：O631.1[理学—高分子化学]