小果酸浆总苦味素对慢性皮炎的治疗作用及机制研究  

Investigation of the Treatment and Mechanism of Total Physailins of Physalis minima on Atopic Dermatitis

作　　者：周松林[1,2] 赵焕阁[1] 林映莹[1] 黄用豪[1] 

机构地区：[1]海南医学院热带病重点实验室,海南海口571101 [2]南京师范大学生命科学学院,江苏南京210046

出　　处：《亚太传统医药》2015年第10期10-12,共3页Asia-Pacific Traditional Medicine

基　　金：海南省自然科学基金(808157);海南大型仪器共享补贴基金(120313)

摘　　要：目的:探讨海南小果酸浆总苦味素(Total Physailins of Physalis minima,TPPM)对小鼠慢性皮炎/湿疹的防治作用。方法:采用5%二硝基氯苯(2,4-dinitrochlorobenzene,DNCB)外涂于小鼠背部致敏,5天后用0.1%DNCB于小鼠右耳内侧反复激发,每周3次,共5周,引起慢性皮炎模型,给药组于激发后涂抹TPPM。结果:用药5周后,TPPM能明显减轻鼠耳肿胀度,减少结痂动物数及浸润炎症细胞数,且能降低小鼠血清中升高的IgE水平以及升高血清中降低的IL-2水平。结论:TPPM能有效抑制小鼠慢性皮炎、湿疹,其作用机制可能与降低IgE水平以及升高IL-2水平有关。Objective：To explore the effects total physailins of Physalis minima（TPPM）, a traditional Chinese folk medicine, on chronic dermatitis in mice induced by 2,4-dinitrochlorobenzene （DNCB）. Methods：Therty six mice were randomly divided into six group. Twenty-five mieroliters of 0.1 % DNCB in acetone/olive oil （3 ： 1） was applied to each side of right ears and dorsal skin three times with 7d intervals in 5 weeks. Mice in different groups were applied prednisolone and TPPM respectively after each challenge. Weight difference of two ears, pathological change of right ear and dermal inflammatory cell number, and examine the content of total serum Ig E and IL-2 levels were used to assess the effects of the drugs. Results：after the 5 weeks challenge, weight differences of two ears in the TPPM group and prednisolone group were significantly decreased as compared with that in the others, and also led to the remarkable suppression of the development of dermatitis, as determined by a histological examination and the serum Ig E lev els, and rose the serum IL 2 level. Conclusion ： TPPM has an obvious effect in treatment of chronic dermatitis in mice.

关 键 词：慢性皮炎 湿疹 小果酸浆总苦味素 

分 类 号：R285.5[医药卫生—中药学] R246.7[医药卫生—中医学]