自拟热哮宁汤对支气管哮喘急性发作期患者血清TXB2和6-ket-PGF-1α水平的影响  

Effect of self-made Rexiaoning Decoction on serum TXB2,6-ket-PGF-1α level of bronchial asthma patients in acute attack

作　　者：胡赛[1] 黄艳[1] 吴小宁[1] 

机构地区：[1]长沙市第四医院急诊科,湖南410006

出　　处：《现代医药卫生》2015年第10期1448-1449,1452,共3页Journal of Modern Medicine & Health

基　　金：湖南省中医药科研计划项目(201251)

摘　　要：目的观察自拟热哮宁汤配合常规治疗对支气管哮喘急性发作期辨证为热哮证患者血清血栓素B2(TXB2)和6-酮基-前列腺素-1α(6-ket-PGF-1α)的影响。方法选择支气管哮喘急性发作期(辨证为热哮证)患者96例,随机分为两组,每组各48例。对照组予以支气管扩张剂联合类固醇激素为基础的常规治疗,治疗组在此基础上加用热哮宁汤口服。治疗前和治疗3 d后通过测定肺通气功能判断临床疗效,同时使用酶联免疫吸附试验法测定血清TXB2和6-ket-PGF-1α水平。结果治疗组临床总控制率显著高于对照组,差异有统计学意义(P<0.05),且较对照组更为显著地降低血清TXB2及升高血清6-ket-PGF-1α水平,差异均有统计学意义(P<0.05)。结论热哮宁汤口服配合常规治疗对支气管哮喘急性发作期辨证为热哮证患者临床疗效更好,较常规治疗更能改善TXB2和6-ket-PGF-1α等细胞因子分泌,可作为支气管哮喘急性发作期治疗的重要手段。Objective To observe the effect of self-made Rexiaoning decoction uniting conventional therapy on serum thromboxane B2 （TXB2） and 6-ket-PGF-lot of bronchial asthma patients in acute attack,i.e, heat asthma patients. Methods Randomly divided 96 selected bronchial asthma patients in acute attack （i.e. heat asthma patients） into two groups,48 in each. Gave bronchodilators and steroid hormone as basic conventional therapy to both groups,while adding Rexiaoning decoction to treatment group. Judged the clinical therapeutic effect by determining pulmonary ventilation functions before treatment and after three days of treatment. Also used enzyme linked immunosorbent assay to determine TXB2 and 6-ket-PGF-lot level. Results The total control rate of treatment group was clearly higher than that of control group, difference showing statistic significance （P〈0.05）. Treatment group prominently reduced TXB2 and rose 6-ket-PGF-lot level comparing to control group, difference showing statistic significance （P〈0.05）. Conclusion The clinical therapeutic effect of Rexiaoning decoction uniting conventional therapy is better than just using conventional therapy on bronchial asthma patients in acute attack ,i.e. heat asthma patients. It is more likely to im- prove TXB2 and 6-ket-PGF-lot cytokines secreting and can be used as an important method to treat bronchial asthma patients in acute attack.

关 键 词：哮喘 血栓烷B2/血液 6-酮前列腺素F1α/血液 热哮宁汤 

分 类 号：R593[医药卫生—内科学]