肺炎克雷伯菌2884株临床分析  

Clinical analysis of 2884 strains of klebsiella pneumoniae

作　　者：王伟程[1] 邱景富[1] 

机构地区：[1]重庆医科大学公共卫生与管理学院,重庆400016

出　　处：《现代医药卫生》2015年第10期1463-1465,共3页Journal of Modern Medicine & Health

基　　金：国家自然科学基金资助项目(31071093)

摘　　要：目的分析肺炎克雷伯菌临床分布及药敏情况,为临床合理治疗该菌感染提供实验室依据。方法收集重庆医科大学附属第一医院2012年8月至2014年8月住院患者各类标本中分离的肺炎克雷伯菌2 884株,对其临床分布及药敏试验结果进行回顾性分析。结果在收集到的临床各种标本中,痰液中肺炎克雷伯杆菌检出率最高,血液检出率最低,主要分布在呼吸内科等各个重症监护病房;产超广谱β-内酰胺酶(ESBLs)肺炎克雷伯菌对氨苄西林耐药率高达100.00%,对其他抗生素也呈不同程度耐药,亚胺培南及含β-内酰胺酶类抑制剂的复方制剂类抗生素是合理有效的治疗药物。结论该院临床分离的肺炎克雷伯菌主要来自痰液,对多种抗菌药物呈耐药倾向,应加强临床标本送检,进行耐药性监测,根据药敏结果合理用药。Objective To analyze clinical distribution and drug allergy of klebsiella pneumoniae. To provide laboratory ground for reasonable clinical therapy for this infection. Methods Collected 2 884 strains of klebsiella pneumoniae separated from various kinds of samples of inpatients admitted in the First Affiliated Hospital of Chongqing Medical University from August, 2012 to August, 2014 and retrospectively analyzed its clinical distribution and drug snsceptibility test outcomes. Results Among all kinds of samples sputum had the highest klebsieUa pneumoniae detection rate,while blood samples had the lowest. It was mainly distributed in respiratory medicine department and other ICUs. The drug resistance rate of extended spectrum beta-lacta- mases （ESBLs）-producing klebsiella pneumoniae to ampicillin reached up to 100.00%. ESBLs-producing klebsiella pneumoniae had different resistance to other antibiotics. Imipenem and compound preparation antibiotics containing beta-lactam inhibitor were reasonable and effective treatment drugs. Conclusion The main source of clinical separated klebsiella pneumoniae is sputum, and it has drug resistance to various antibacterial drugs. Should strengthen to submitt clinical samples more often and monitor drug resistance. Apply medicine according to drug susceptibility test outcome.

关 键 词：β内酰胺酶类/分析 抗药性 微生物 克雷伯菌 肺炎/酶学 克雷伯菌 肺炎/药物作用 

分 类 号：R978.11[医药卫生—药品]