^(131)I治疗Graves病患者1年后社会心理状况及生活质量研究  

Social psychological status and quality of life in Graves' disease patients one year after ^(131)I treatment

作　　者：胡斌[1] 成莉霞[1] 曹晓征[1] 

机构地区：[1]河南科技大学第一附属医院核医学科,河南洛阳471003

出　　处：《中国现代医学杂志》2015年第13期61-65,共5页China Journal of Modern Medicine

摘　　要：目的探讨Graves病患者在接受131I治疗1年后的社会心理状况及生活质量。方法选取2008年7月-2013年6月在该科接受131I治疗的GD患者368例,归为病例组,并选取同期来该院体检的健康成人105例,归为对照组。对病例组患者进行随访1年,根据治疗后第6和12个月的临床结局分为甲状腺功能正常组、甲亢组、甲减组、亚临床甲亢组和亚临床甲减组,比较各组的焦虑自评量表(SAS)、抑郁自评量表(SDS)、社会支持评定量表(SSRS)和世界卫生组织生存质量测定简表(WHOQOL-BREF)的评分。结果 42例患者在1年的随访中失访,失访率为11.41%。病例组治疗前后的SAS与SDS量表评分均明显高于对照组(P<0.05),SSRS与WHOQOL-BREF各领域的评分均明显低于对照组(P<0.05)。病例组治疗后的SAS与SDS量表评分均明显低于治疗前(P<0.05),SSRS与WHOQOL-BREF各领域的评分均明显高于治疗前(P<0.05)。病例组治疗后第12个月的WHOQOL-BREF心理领域的评分明显高于治疗后第6个月(P<0.05),其他评分比较差异无统计学意义(P<0.05)。对照组的SAS与SDS量表评分均明显低于正常组(P<0.05),SSRS与WHOQOL-BREF各领域的评分均明显高于正常组(P<0.05)。并且正常组的SAS与SDS量表评分均明显低于其他临床结局患者(P<0.05),SSRS与WHOQOL-BREF各领域的评分均明显高于其他临床结局患者(P<0.05)。结论 GD患者治疗1年后的社会心理状况及生活质量较治疗前有明显改善,但未恢复到健康成人的水平,应进行积极的心理干预,改善患者的预后。【Objective】To investigate the social psychological status and quality of life in Graves＇ disease（GD）patients who received131 I treatment with one year of follow-up.【Methods】A total of 368 patients with GD who received131 I treatment from July 2008 to June 2013 were enrolled for study and classified as the case group. Totally105 healthy adults who received physical examination over the same period were selected and classified as the control group. Patients were followed up for one year after treatment, and then divided into normal thyroid function group, hyperthyroidism group, hypothyroidism group, subclinical hyperthyroidism group and subclinical hypothyroidism group according to the clinical outcomes at 6th month and 12 th month. The scores of Self-rating anxiety scale（SAS）, Self-rating depression scale（SDS）, Social support rating scale（SSRS） and World Health Organization Quality of Life Brief Scale（WHOQOL-BREF） were compared among all groups. 【Results】 Forty-two patients（11.41%） were lost in the one year of follow-up. The scores of SAS and SDS in the case group before and after treatment were all significantly higher than those of control group（P〈0.05）, while the scores of SSRS and WHOQOL-BREF were all significantly lower than those of control group（P〈0.05）. The scores of SAS and SDS in the case group after treatment were all significantly lower than those before treatment（P〈0.05）, while the scores of SSRS and WHOQOL-BREF were all significantly higher than those before treatment（P〈0.05）. The score of psychological domain of WHOQOL-BREF in the case group at 12 th month after treatment was significantly higher than those at 6th month（P〈0.05）, and there were no significant differences in other scores between them（P〉0.05）. The scores of SAS and SDS in the control group were all significantly lower than those in normal group（P〈0.05）, while the scores of SSRS and WHOQOL-BREF were all significantly higher than those in normal group（P〈0

关 键 词：GRAVES病 131-碘 社会心理状况 生活质量 

分 类 号：R581.3[医药卫生—内分泌]