地特胰岛素联合二甲双胍治疗对新诊断2型糖尿病胰岛功能及高敏C反应蛋白的影响  

Influence of insulin detemir combined with metformin on islet function and hs-CRP in newly diagnosed type 2 diabetes mellitus

作　　者：廖丽娅[1] 邓红艳[1] 韦煊[1] 

机构地区：[1]华中科技大学同济医学院附属武汉市普爱医院内分泌科,湖北武汉430030

出　　处：《中国现代医学杂志》2015年第13期66-68,共3页China Journal of Modern Medicine

摘　　要：目的观察地特胰岛素联合二甲双胍治疗糖化血红蛋白(Hb A1c)≥9.0%的初诊2型糖尿病患者的疗效及对胰岛细胞和C反应蛋白的影响。方法选取50例新诊断Hb A1c≥9.0%的2型糖尿病患者,给予地特胰岛素联合二甲双胍治疗,疗程12周,观察治疗前后体重指数(BMI)、空腹血糖(FBG)、糖化血红蛋白(Hb A1c)、胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白胆固醇(LDL-C)、胰岛素抵抗指数(HOMA-IR)、胰岛素分泌指数(HOMA-β)和高敏C反应蛋白(hs-CRP)等指标变化,记录低血糖事件。结果治疗12周后,患者的FPG、Hb A1c、TC、TG、LDL-C、hs-CRP和HOMA-IR水平较治疗前均明显下降(P<0.05),而HOMA-β水平明显升高(P<0.05),BMI值无明显改变(P>0.05)。结论地特胰岛素联合二甲双胍治疗新诊断Hb A1c≥9.0%的2型糖尿病,在有效降糖、降脂的同时,更好改善了胰岛β细胞功能,且不增加体重和低血糖风险性,有效、安全。【Objective】To observe the influence of insulin detemir combined with metformin on islet function and C-reactive protein（CRP） level in newly diagnosed type 2 diabetes mellitus with Hb A1 c ≥9.0%.【Methods】Fifty newly diagnosed type 2 diabetes mellitus were treated with insulin detemir and metformin for 12 weeks, the body mass index（BMI）, fasting blood glucose（FBG）, glycosylated hemoglobin A1c（HbA1c）, TC, TG, LDL-C and hs-CRP level before and after treatment were observed, and the incidence of hypoglycemia was recorded. HOMA-IR and HOMA-β were calculated according to the formula, and then the effect was evaluated. 【Results】After 12-weeks therapy, FBG, Hb A1 c, TC, TG, LDL-C, hs-CRP, HOMA-IR level were significantly decreased（P〈0.05）,HOMA-β level was increased significantly（P〈0.05）, while BMI showed no obvious changes（P〉0.05）.【Conclusions】Insulin detemir combined with metformin can improve islet function, and it is an effective and safe therapeutic choice for newly diagnosed type 2 diabetes mellitus with Hb A1 c ≥9.0%.

关 键 词：地特胰岛素 2型糖尿病 胰岛功能 高敏C反应蛋白 

分 类 号：R587.1[医药卫生—内分泌]