中国人群β_3肾上腺素能受体基因Trp64Arg多态性与原发性高血压关联的荟萃分析  

β_3-adrenergic receptor Trp64Arg polymorphism and essential hypertension in a Chinese population: a metaanalysis

作　　者：许建新 李宏伟[2,3] 杨春菊 周俊萍 张乐 张平[2,3] 

机构地区：[1]曲靖医学高等专科学校,云南曲靖655000 [2]曲靖市第一人民医院 [3]昆明医科大学附属曲靖医院,云南曲靖655000 [4]重庆市渝北区人民医院,重庆401120

出　　处：《中国现代医学杂志》2015年第13期78-82,共5页China Journal of Modern Medicine

摘　　要：目的系统评价β3肾上腺素能受体（ADRB3）基因Trp64Arg多态性与中国人群原发性高血压的易感关系。方法检索中国知识资源总库、万方数据资源系统和美国国立医学图书馆数据库（PubMed）等数据库,收集有关文献资料。根据异质性检验结果合并数据,计算优势比并进行发表偏倚评估和敏感性分析。结果共14篇文献符合条件纳入研究,包括4 050例原发性高血压患者和4050例对照者,采用固定效应模型合并数据,结果显示ADRB3基因Trp64Arg多态性在等位基因（OR=1.17,95%CI：1.06-1.28,P=0.0020）、显性模型（OR=1.20,95%CI：1.08-1.34,P=0.0008）和杂合子模型（OR=1.21,95%CI：1.08-1.36,P=0.0009）与中国人群原发性高血压相关。结论 ADRB3基因Trp64Arg多态性与中国人群原发性高血压易感性相关,A等位基因可能是原发性高血压的遗传危险因素。【Objective】To investigate the relationship between the β3-adrenergic receptor Trp64 Arg polymorphism and essential hypertension（EH） in a Chinese population. 【Methods】A literature search was carried out on CNKI, Wanfang data, Pub Med etc. The pooled odds ratio（OR） and their corresponding 95% confidence intervals（CI）were calculated by a fixed or random effect model, and publication bias and sensitivity were further analyzed.【Results】Data from 14 controlled trials were included in this review（including 4,050 participants of EH group and4050 participants of control group）. A significant relationship between the β3-adrenergic receptor Trp64 Arg polymorphism and EH in the pooled Chinese population was found in an allelic genetic model（OR=1.17, 95%CI： 1.06-1.28,P =0.002）, a dominant model（OR=1.20, 95%CI： 1.08-1.34, P = 0.0008）, and a heterozygote model（OR=1.21, 95%CI： 1.08-1.36, P = 0.0009）. 【Conclusions】The β3-adrenergic receptor Trp64 Arg polymorphism may play a role in the susceptibility of EH, and A allele may be a risk factor for EH in a Chinese population.

关 键 词：高血压 Β3肾上腺素能受体 多态性 荟萃分析 

分 类 号：R544.1[医药卫生—心血管疾病]