母乳中多溴联苯醚-47浓度的meta分析（英文）  

Polybrominated Diphenyl Ether-47 Concentrations in Human Milk: A Meta-Analysis

作　　者：任征[1] 戴瑞雪[1] 丁承辉[1] 翟金霞[1] 

机构地区：[1]安徽医科大学公共卫生学院劳动卫生与环境卫生学系,安徽230032

出　　处：《环境与职业医学》2015年第5期444-451,共8页Journal of Environmental and Occupational Medicine

基　　金：Grant for Scientific Research of BSKY(NO.XJ201201)from Anhui Medical University and Anhui Provincial Natural Science Foundation(NO.201408085MH192)

摘　　要：[目的]多溴联苯醚-47（PBDE-47）具有较长的半衰期,能够在食物链中保持很长时间;多项调查发现人乳中PBDE-47具有较高的浓度。本文旨在阐述母乳中PBDE-47的浓度水平及影响该浓度的相关因素。[方法]检索自建库至2014年10月以来的有关数据库,包括Pub Med、中国知网（CNKI）、中国生物医学文献数据库（CBM）,查找并分析符合纳入标准的相关文献,采用Stata 11.0软件进行统计分析。[结果]共纳入分析了24篇文献研究。采用随机效应模型（I 2=99.8%,P=0.25）分析发现,人乳中PBDE-47浓度为12.847（95%CI=2.42~23.272）ng/g。亚组分析发现：初产妇乳汁中PBDE-47浓度为1.388（95%CI=0.850~1.926）ng/g,高于经产妇乳汁中的浓度0.708（95%CI=0.394~1.023）ng/g;妊娠年龄分析显示,〈28年龄组中的浓度为0.441（95%CI=0.174~0.709）ng/g,28~31年龄组中的浓度为1.679（95%CI=0.968~2.389）ng/g,〉31年龄组中的浓度为1.152（95%CI=0.393~1.911）ng/g。[结论]孕期暴露PBDE-47会导致母乳中PBDE-47的升高,PBDE-47的浓度与妊娠年龄和经产次数有关。[Objective] Polybrominated diphenyl ether-47（PBDE-47） is detected abundantly in human milk. Its long halflife compared to most of other congeners makes it remaining in the food chain for a long time. The aim of this meta-analysis is to summarize results and related factors on the concentrations data of PBDE-47 in human milk. [Methods] A computer search was carried out for literature pertaining to the concentrations of PBDE-47 up to October 2014. We searched all available electronic papers by certain keywords in Pubmed, China National Knowledge Infrastructure（CNKI）, and Chinese Biomedical Literature Database（CBM） databases. Proper literatures were included in this study according to the inclusion criteria. Statistical analysis was performed using Stata 11.0 software. [Results] A total of 25 studies in 24 articles were included in this meta-analysis. The meta-analysis revealed the average PBDE-47 concentration was 12.847（95%CI=2.422-23.272） ng/g lipid. Data were assessed using the random-effects model（I 2=99.8%, P=0.25）. In the subgroup analysis, the concentrations were 1.388（95%CI=0.850-1.926） ng/g lipid for studies in primipara, which was higher than those of the multipara 0.708（95%CI=0.394-1.023） ng/g lipid. In the subgroup analysis of maternal age, the average PBDE-47 concentration was 0.441（95%CI=0.174-0.709） ng/g lipid for maternal age 28 years, which was lower than those of 28-31 years [1.679（95%CI=0.968-2.389） ng/g lipid], and the average PBDE-47 concentration was 1.152（95%CI=0.393-1.911） ng/g lipid for maternal age 31. [Conclusion] This study demonstrates the exposure of pregnant women to PBDE-47 would lead to the presence of PBDE-47 in human milk and its concentration is varied by maternal age and parity.

关 键 词：多溴联苯醚-47 母乳 人体暴露 META分析 

分 类 号：R173[医药卫生—妇幼卫生保健]