右美托咪定复合丙泊酚用于无痛纤维结肠镜检查的临床疗效及安全性评价  

Clinical efficacy and safety of dexmedetomidine combined with propofol on analgesic coloscopy

作　　者：曾雪云[1] 徐天生[1] 徐建光[1] 兰永平[1] 

机构地区：[1]衢州市人民医院普外科,浙江衢州324000

出　　处：《中国临床药理学杂志》2015年第10期796-798,共3页The Chinese Journal of Clinical Pharmacology

基　　金：浙江衢州市科技基金资助项目(2014P022)

摘　　要：目的：评价右美托咪定复合丙泊酚用于无痛纤维结肠镜检查术的临床疗效及安全性。方法将48例拟进行纤维结肠镜检查的患者随机分为试验组22例和对照组26例。对照组静脉注射丙泊酚2.5 mg· kg-1，术中根据患者麻醉情况追加0.5～1.0 mg· kg-1。试验组首先缓慢静脉推注（10 min ）右美托咪定1μg· kg-1，然后静脉注射丙泊酚2 mg· kg -1。2组患者麻醉后置入纤维结肠镜，并寻腔进镜对患者肠腔内壁进行检查。检查过程中分析比较2组患者的镇痛效果、起效时间、苏醒时间、离院时间及麻醉过程中的不良反应发生率有无差别。结果试验组镇痛效果明显优于对照组（ P＜0.05）。试验组起效时间、苏醒时间及离院时间均明显短于对照组，丙泊酚用量小于对照组（均P＜0.05）。试验组头晕及躁动发生率显著低于对照组（均P＜0.05），而恶心呕吐、舌后坠及呼吸抑制发生率比较差异均无统计学意义（ P＞0.05）。结论右美托咪定复合丙泊酚用于无痛纤维结肠镜检查镇痛效果好，不良反应发生率低。Objective To explicate the effects and safety of propofol com-bined with dexmedetomidine on analgesic coloscopy .Methods A total of 48 patients planed for analgesic coloscopy were randomly divided into control group （ n=26 ） and experiment group （ n=22 ） .Patients in the control group received propofol 2.5 mg· kg-1 with plus of 0.5 -1.0 mg· kg-1 intraoperatively and patients in the experiment group received dexmedetomidine 1μg· kg-1 firstly followed by propofol 2.5 mg· kg-1 . The procedure of fiber colonoscopy was done after anesthesia , the inner lumen was examined by the colonoscopy . In the procedure of examination , the analgesia effect time , wake up time , leave hospital time and incidence of odverse event between the two groups were compared . Results The analgesia effects was superior in the experiment compared with control group （ P 〈0.05 ） .The time of effectiveness recovery and leave hospital was significant shorter in experiment group compared with control group （ P 〈0.05 ） .The amount of propofol used in experiment group was smaller than control （ P 〈0.05 ） .The incidence of dizziness and restlessness was smaller in experiment group compared with control group （ P 〈0.05 ） . Conclusion Dexmedetomidine combined with propofol was efficacy and safe on analgesic coloscopy patients .

关 键 词：纤维结肠镜 无痛 右美托咪定 丙泊酚 安全性 

分 类 号：R971.2[医药卫生—药品] R574.6[医药卫生—药学]