地诺前列酮与双球囊导管用于促宫颈成熟的临床疗效及安全性评价  

Clinical efficacy and safety evaluation of dinoprostone and double balloon catheter for cervical ripening

作　　者：郑美凤[1] 郑东月[1] 

机构地区：[1]温州医科大学附属第二医院产科,浙江温州325000

出　　处：《中国临床药理学杂志》2015年第10期824-826,共3页The Chinese Journal of Clinical Pharmacology

摘　　要：目的评价地诺前列酮与双球囊导管用于促宫颈成熟的临床疗效和安全性。方法将208名Bishop评分≤6的产妇随机分为试验组105例和对照组103例。试验组用双球囊导管促宫颈成熟,对照组将1枚地诺前列酮10 mg置于阴道穹窿的深处用于促宫颈成熟。记录在24 h内分娩的相关数据,比较2组的临床疗效和不良反应发生率。结果试验组24 h内经阴道分娩成功的比例较对照组高(68.57%vs 49.51%,P<0.05)。剖宫产率在2组间差异无统计学意义(23.81%vs 26.21%,P>0.05)。试验组催产素和硬膜外镇痛的使用率较对照组高(P<0.05),而对照组子宫张力过大和宫缩过频发生率较试验组高(P<0.05)。结论双球囊导管用于促宫颈成熟较地诺前列酮可以增加24 h内阴道分娩成功率。Objective To evaluation the clinical efficacy and safety of dinoprostone and double balloon catheter for cervical ripening . Methods A total of 208 women with Bishop score less than 6 were ran-domly divided into treatment group （ n =105 ） and control group （ n =103）.Patients in treatment group were given double balloon catheter for cervical ripening , and patients in control group were given dinoprostone for cervical ripening.The data of vaginal delivery in 24 hours, clinical efficacy and incidence of adverse drug reactions were recorded and com-pared between the two groups.Results The proportion of women who a-chieved vaginal delivery in 24 hours was higher in the treatment group than in the control group （68.57% vs 49.51%,P〈0.05）.There was no difference in cesarean delivery rates between the two groups （ 23.81%vs 26.21%, P〉0.05 ） .Oxytocin and epidural analgesia were adminis-tered more frequently in treatment group （P〈0.05）.Uterine tachysystole or hypertonus occurred more frequently in the control group （ P〈0.05 ） . Conclusion Double-balloon catheter can improve the for vaginal birth within 24 hours in the treatment of cervical ripening .

关 键 词：宫颈成熟 双球囊导管 地诺前列酮 前列腺素 

分 类 号：R714.3[医药卫生—妇产科学] R984[医药卫生—临床医学]