复方苦参注射液联合伽玛刀治疗局部晚期胰腺癌临床研究  

Clinical Study on Compound Sophora Flavescentis Radix(Kushen) Injection Combined with Gamma Knife for Treatment of Locally Advanced Pancreatic Carcinoma

作　　者：王磊[1] 李灵招[2] 王晓芳[3] 单国用[1] 刘蕊 张松[1] 吴晓东[5] 

机构地区：[1]郑州人民医院,河南郑州450003 [2]郑州市中心医院,河南郑州450001 [3]郑州大学第三附属医院,河南郑州450003 [4]许昌市第五人民医院,河南许昌460000 [5]郑州市儿童医院,河南郑州450004

出　　处：《中国中医药信息杂志》2015年第6期21-24,共4页Chinese Journal of Information on Traditional Chinese Medicine

摘　　要：目的评价复方苦参注射液联合伽玛刀治疗局部晚期胰腺癌的临床疗效。方法将65例局部晚期胰腺癌患者随机分为单纯伽玛刀治疗组(A组)32例和复方苦参注射液联合伽玛刀治疗组(B组)33例。分别于治疗后1、3、6、9、12个月行增强CT扫描及CA199检查,此后每6个月复查1次,共随访36个月。观察2组近期及远期疗效,并进行生存曲线分析。结果临床受益率A组为53.13%,B组为84.85%(P=0.006)。中位生存时间A组为11.00个月,B组为23.00个月;平均生存时间A组为16.37个月,B组为22.28个月(P=0.017)。2组患者均按计划顺利完成治疗,未出现胰漏、皮肤灼伤、脏器穿孔及放射性肠炎等严重并发症。结论复方苦参注射液联合伽玛刀治疗局部晚期胰腺癌安全、有效,在改善生活质量特别是控制癌痛方面具有明显优势。Objective To evaluate the clinical efficacy of Compound Sophorae Flavescentis Radix （Kushen） Injection combined with gamma knife for treatment of locally advanced pancreatic carcinoma. Methods Totally 65 patients of locally advanced pancreatic cancer were randomly divided into two groups：32 cases of simple gamma knife group （group A）, 33 cases of Compound Kushen Injection combined with gamma knife treatment （group B）. Patients received enhancement computed tomography scanning and CA199 review at 1, 3, 6, 9, 12 months after treatment, and once every six months, a total of 36 months of follow-up. Short-term and long-term efficacy was observed after treatment, and survival curve analysis was carried out. Results Clinical benefit response was 53.13% in group A and 84.85% in group B （P=0.006）;median survival time of two groups was 11.00 months in group A and 23.00 months in group B;the average survival time in group A was 16.37 months, and 22.28 months in group B （P=0.017）. In the two groups, treatment of the 65 patients was completed smoothly as planned, and no one had serious complications, such as pancreatic leakage, skin burns, viscera perforation and radioactive enteritis. Conclusion Compound Kushen Injection combined with gamma knife can treat locally advanced pancreatic carcinoma safely and efficiently, which can improve patients’ life quality, especially in cancer pain control.

关 键 词：胰腺癌 复方苦参注射液 伽玛刀 

分 类 号：R273.59[医药卫生—中西医结合]